2019
DOI: 10.1111/jvim.15433
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Pharmacokinetics of meloxicam after oral administration of a granule formulation to healthy horses

Abstract: Background Nonsteroidal anti‐inflammatory drugs are administered in horses for several systemic diseases. Selective cyclooxygenase‐2 inhibitors are preferred because of lower risk of adverse effects. Several meloxicam formulations have been tested in horses, but a recently marketed granule oral formulation has not been studied. Objective To characterize the pharmacokinetics of a novel granule meloxicam formulation in fasted and fed horses, and to compare pharmacokinetic features with oral suspension and tablet… Show more

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Cited by 9 publications
(9 citation statements)
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“…Meloxicam has received substantial interest in recent years, with 71 separate articles considering its efficacy, pharmacokinetics, pharmacodynamics and toxicity in a range of species included in the current review [ 82 , 86 , 87 , 95 , 133 , 134 , 175 , 176 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 235 , 255 , 257 , 258 , 259 , 306 , 307 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , …”
Section: Resultsmentioning
confidence: 99%
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“…Meloxicam has received substantial interest in recent years, with 71 separate articles considering its efficacy, pharmacokinetics, pharmacodynamics and toxicity in a range of species included in the current review [ 82 , 86 , 87 , 95 , 133 , 134 , 175 , 176 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 235 , 255 , 257 , 258 , 259 , 306 , 307 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , …”
Section: Resultsmentioning
confidence: 99%
“…Half-life 15.4 h [191] 10.69 h [190,192] 14.59-27.54 h [175,176,195,200,201] 10-34 h [202] Iguana: 12.96 h [196] Llama: 22.7 h [197] Pig: 6.83 h [198] MEC MEC * * MEC is based on the minimum dose rate at which suppression of prostaglandin or thromboxane production has been reported. # Data presented relate to RWJ-20142, the active acid metabolite of tepoxalin.…”
Section: Meloxicam (Oral)mentioning
confidence: 99%
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“…Regarding the other veterinary species, although fed/fasted studies may be published in horses [ 29 ] and swine [ 30 ], species such as cattle, horses, poultry, and swine typically have levels of residual material within their stomachs throughout the day. In nature, horses rarely exist in a fasted state [ 31 ].…”
Section: Unique Dosage Considerations In Veterinary Medicinementioning
confidence: 99%
“…Meloxicam possesses various beneficial actions that make it a model NSAID for use in animals, including extended elimination half-life, low gastrointestinal toxicity, suitable oral and injectable absorption rates, and good bioavailability [ 2 , 3 , 4 ]. The pharmacokinetic (PK) profile of meloxicam has been studied in several companion, wildlife, and production species including koalas [ 5 ], guinea pigs [ 6 ], dogs [ 7 ], cats [ 8 ], birds [ 9 ], cattle [ 10 ], horses [ 11 ], and sheep [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%