Pharmacokinetics of Low- and High-Dose Intravenous Diatrizoate Contrast Media Administration

Feldman, Stuart; La, Hayman; Hulse, Michael

doi:10.1097/00004424-198401000-00013

Cited by 11 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For metrizoate, a halflife of 105 min has been reported in cases with normal renal function [9], while the mean value observed during hemodialysis with the Kiil artificial kidney was 3 h 55 min [5]. Also for diatrizoate an increase in half-life during hemodialysis has been found compared to subjects with normal renal function [8,[10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Elimination of lohexol, a Low Osmolar Nonionic Contrast Medium, by Hemodialysis in Patients with Chronic Renal Failure

Waaler¹,

Svaland²,

Fauchald

et al. 1990

Nephron

View full text Add to dashboard Cite

The dialyzability of iohexol was examined in patients with chronic renal failure on long-term hemodialysis treatment. Eight patients had iohexol (Omnipaque® 240 or 350 mg I/ml) injected in doses between 98 and 1,493 mg I/kg body weight (BW) 25 h (mean time) before start of hemodialysis. Dialysance of iohexol was 81 ± 15 ml/min (mean ± SD) compared to 120 ± 16.8 ml/min for creatinine. Elimination half-life for iohexol during hemodialysis was 3.9 ± 1.1 h while plasma clearance was 64 ± 17 ml/min. The distribution volume calculated (0.25 ± 0.05 liters/kg BW) confirms previous observations with distribution in the extracellular fluid only. Before the start of hemodialysis 36 ± 28% of the dose injected was eliminated, indicating some extrarenal elimination. After 4 h of hemodialysis 72 ± 11% of the dose was removed.

show abstract

Section: Discussionmentioning

confidence: 99%

Elimination of lohexol, a Low Osmolar Nonionic Contrast Medium, by Hemodialysis in Patients with Chronic Renal Failure

Waaler¹,

Svaland²,

Fauchald

et al. 1990

Nephron

View full text Add to dashboard Cite

show abstract

“…The majority of pharmacokinetic analyses of the conventional contrast media have used this type of 2-compartmental analysis [13][14][15][16][17][18][19]. As an alternative nomenclature, a and /?…”

Section: Contrast Agent Pharmacokineticsmentioning

confidence: 99%

The quantification of renal function with enhanced computed tomography

Blomley¹,

Dawson²

1996

The British Journal of Radiology

View full text Add to dashboard Cite

The changes with time in renal parenchymal and vascular attenuation following injection of an intravascular contrast medium can be exploited to study renal physiology in several ways. Shortly after injection, both contrast medium clearance and fractional vascular volume per unit volume of kidney can be measured on a regional basis by obtaining sequential CT data from one anatomical level and the application of a graphical analysis to the baseline subtracted CT numbers for tissue and vascular regions of interest: c(t) and b(t), respectively. By plotting the ratio c(t)/b(t) against integral of b(t)dt/b(t), both fractional vascular volume and contrast medium clearance can be estimated graphically. At later time points, a semilogarithmic plot against time of the declining attenuation of vascular or parenchymal regions of interest gives information about overall, as opposed to regional, renal function: the gradient estimates the glomerular filtration rate per unit volume of extracellular fluid. Absolute glomerular filtration rates can also be calculated with blood sampling. Although further experimental evaluation is needed, these techniques have a strong theoretical basis, and experimental work performed so far is encouraging. Possible applications of these techniques are discussed.

show abstract

“…The per cent release from each contrast agent was compared with release from normal saline by analysis of variance. study, 3 mg iodine/ml, is attained or exceeded in the serum for several minutes following an intravenous bolus administration of CM (2,4,13). The extracellular fluid space equilibrates rapidly with serum (9).…”

Section: Resultsmentioning

confidence: 99%

Effect of Contrast Media on Beta-Endorphin Secretion

Harnish¹,

Zuniga²,

Northington³

et al. 1988

Acta Radiol

View full text Add to dashboard Cite

The central nervous system may be highly susceptible to the toxic effects of contrast media (CM). Previous experiments demonstrated that vasopressin is released after the intravenous administration of CM. The present study examined the response of the opiocortin system to CM. Neurons of the rat basal hypothalamus, dispersed and attached to Cytodex-3 beads, were perfused with sodium diatrizoate, metrizamide or iohexol (3 mg iodine/ml). The eftluent was collected, and the beta-endorphin (B-E) content was measured by a radioimmunoassay technique. Results, normalized to the internal positive control, were compared with release from normal saline (negative control) by analysis of variance. Diatrizoate and metrizamide caused significant release of B-E (p <0.03). Iohexol did not stimulate release of B-E. These results suggest that diatrizoate and metrizamide, but not iohexol, can stimulate the release of hormones from hypothalamic neurons. The phenomenon may play a role in some reactions to intravascular CM administration since these neurons are not protected by a blood-brain barrier.

show abstract

Pharmacokinetics of Low- and High-Dose Intravenous Diatrizoate Contrast Media Administration

Cited by 11 publications

References 0 publications

Elimination of lohexol, a Low Osmolar Nonionic Contrast Medium, by Hemodialysis in Patients with Chronic Renal Failure

Elimination of lohexol, a Low Osmolar Nonionic Contrast Medium, by Hemodialysis in Patients with Chronic Renal Failure

The quantification of renal function with enhanced computed tomography

Effect of Contrast Media on Beta-Endorphin Secretion

Contact Info

Product

Resources

About