“…The large litter size and individual fetal sacs allow for serial maternal blood, placental, fetal and amniotic fluid sampling, making it even more useful for pharmacokinetic studies. The pregnant rat model has been utilized in maternal-fetal drug transfer studies of a variety of compounds, including AZT (Boike et al, 1989a,b;Heffez et al, 1990;Dawson et al, 1990;Fujinaga et al, 1991;Beachy et al, 1993;Ostrea et al, 1994;Huang et al, 1996;Brown et al, 2003).…”