Pharmacokinetics of Gentamicin in Rabbits Pretreated with Nonsteroidal Anti-Inflammatory Drugs: An Interaction Study

Therapeutic Drug Monitoring in Interstitial Fluid: A Feasibility Study Using a Comprehensive Panel of Drugs

“…Gentamicin, an aminoglycoside, is widely used to treat a variety of Gram‐negative infections 10. The dose of gentamicin (50 mg/kg) in our rabbit study ( n = 6) was based on the published data on rabbits 11. Similar to vancomycin, gentamicin showed a reduced C max in ISF (10.8 ± 3.6 µg/mL, mean ± SD) compared with the blood (289.5 ± 40.3 µg/mL) ( p < 0.05) and similar AUCs (176.1 ± 54.0 vs. 188.8 ± 44.7 µg h/mL, respectively) (Table 1).…”

Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development

“…In rats, a single administration of 500 mg/kg of ASA (twice the low teratogenic dose of 250 mg/kg noted in Kimmel et al, 1971( on GD 11 produced a maximum serum salicylate concentration of approximately 45 μg/ml. In rabbits, ASA administered as single oral gavage doses of 175 and 300 mg/kg produced maximum serum salicylate concentrations of 3.7 and 25.7 μg/ml, respectively (Kergueris et al, 1988; Shivprakash et al, 1994). These data indicated that the doses adminis‐tered in our studies would have produced plasma salicylate levels similar to those that induce teratogenicity in rats.…”

Pharmacologic Properties of Ketorolac Tromethamine: A Potent Analgesic Drug

“…Because ketorolac is highly bound to proteins, there is a potential for interactions with other agents highly bound to human serum albumin. In an animal study, ketorolac increased the maximal plasma concentration and reduced the clearance of gentamicin leading to the accumulation of the aminoglucoside (94). Although there is no information regarding the interaction of ketorolac and aminoglucosides in humans, if these drugs are administered concomitantly, patients must be monitored with great care.…”