Pharmacokinetics of gentamicin in llamas

Drug Therapy in Llamas and Alpacas

“…5,6,13,14,31,32,34,37,42,[74][75][76][77][78][79][80][81][82][83][84][85] Pharmacokinetic data must be interpreted in the context of evaluating therapeutic concentrations, which depend on the type of drug and the purpose of the drug. Generalizations of the relationship between the pharmacokinetics and pharmacodynamics of antimicrobials were discussed in a previous section, and relatively good data on how to make decisions with a combination of pharmacokinetic, pharmacodynamic, and in vitro antimicrobial susceptibility data are available.…”

Pharmacokinetics of flunixin meglumine in llamas following a single intravenous dose

“…Until very recently, South American camelids [(SACs), alpacas, guanacos, llamas, and vicunas] have been overlooked in terms of pharmacological research. To our knowledge, pharmacokinetic data is available only for six antimicrobial agents in SACs (Dowling et al. , 1995; Christensen et al.…”

Pharmacokinetics of phenylbutazone in llamas following single intravenous and oral doses

“…Until very recently, SACs have been overlooked in terms of pharmacologic research. To our knowledge, pharmacokinetic data is available only for six antimicrobial agents in SACs (Dowling et al ., 1995; Christensen et al ., 1996; Lackey et al ., 1996). These studies indicate that the pharmacokinetic parameters of antimicrobial drugs differ in some cases from other large animal species, and that dosage regimes should be changed accordingly.…”

“…Pharmacokinetic data is available for only seven drugs in llamas, all antimicrobial agents (Dowling et al ., 1995; Christensen et al ., 1996; Lackey et al ., 1996). Pharmacokinetic parameters for many of these drugs differ from other large animal species, and even from camels, the closest known relative of the SACs (Ebel, 1989).…”