Pharmacokinetics of doxorubicin after intratumoral injection using a thermosensitive hydrogel in tumor-bearing mice

Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery

“…[6][7][8] Intratumoral administration of chemotherapeutic agents is a potentially more effective modality to overcome the described limitation and this has been extensively evaluated using a number of anticancer drugs. 9,10 Such targeted delivery may realize drug localization within the tumor tissue and divert the drug from nontarget organs to improve toxicity and increase efficacy, while decreasing the incidence and the intensity of side effects.…”

“…It is proposed that a drug delivery system is required to ensure the drug is properly localized and that it is released in a controlled way. 11 Several polymeric drug delivery systems have been developed for intratumoral drug delivery, including hydrogels, 9 microparticles, 10 nanoparticles, 12 and nanofibers. 13 Magnetic nanoparticles (MNPs) have been investigated for decades in drug delivery systems because of their high magnetic responsiveness, biodeg radability, biocompatibility, high delivery efficiency and potential targeting function.…”

Doxorubicin-Loaded Zein <i>in Situ</i> Gel for Interstitial Chemotherapy

“…7) In situ gel has become increasingly attractive as a carrier for drug delivery systems because it is injectable, is biodegradable, has simple drug loading and is convenient for dose adjustment. [8][9][10][11][12] Polymers used for in situ gels [13][14][15][16][17] are mainly synthesized. In this study, Zein was used as the base material of an in situ gel for interstitial chemotherapy.…”

“…However, cardiotoxicity has limited its clinical application. 26,27) To reduce its toxicity and increase its selectivity, effective methods have been developed (e.g., co-delivery systems 28) and liposome DDS 29) ) for systemic administration to solid tumors. However, tumor localization and cardiotoxicity can still be improved.…”

Nanotechnology Development and Utilization: A Primer for Diagnostic and Interventional Radiologists

“…Therefore, interventional radiologists should play a role in delivering these therapeutic agents, which may circumvent the barriers to delivery that are intrinsic to the tumor (Fig 7). Intratumoral percutaneous infusion and gel or wafer implantation has been used to deliver a number of therapeutics (65,66). Imaging-guided percutaneous chemical ablation with ethanol or acetic acid is well established, although its efficacy is limited (67).…”