Pharmacokinetics of diflubenzuron in two types of chickens

Opdycke, Joseph C.; Menzer, Robert E.

doi:10.1080/15287398409530534

Cited by 23 publications

(12 citation statements)

References 20 publications

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“…The modeling of PCB flows is based on the principle of concentration equilibrium between compartments. The result is a marked effect of body fat on the speed of decontamination of the tissues, which is in agreement with the experimental results obtained with different strains of laying hens [9] and modeled by MacLachlan [15].…”

Section: Discussionsupporting

confidence: 90%

“…The transfer and accumulation parameters they provide are linked to the characteristics of the animal used for experimentation. As a consequence, it is difficult to apply these empirical models to laying hens, which may have different physiological characteristics, such as egg laying rate and/or body fat, which are known to affect the kinetics of POP transfer [9,10]. Indeed, because of their lipophilic properties, ingested POPs are preferentially stored in fat and subsequently transferred into the egg yolk.…”

Section: Introductionmentioning

confidence: 99%

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Modeling PCB transfer into hen eggs: Influence of physiological characteristics of the animal

Fournier

Martin

Travel

et al. 2014

Enviro Toxic and Chemistry

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Laying hens are likely to be exposed to a wide range of persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs). To improve the safety of poultry farming systems in terms of POPs, the present research focused on assessing the impact of physiological characteristics of the hen on the transfer of ingested PCBs to eggs. Modeling was used as a research tool to explore the impact of some physiological characteristics on the transfer of PCBs in the laying hen. The mathematical model simulates the dynamics of the size of the lipid compartments in the animal and the frequency of laying, with the PCB concentrations in egg yolk and adipose tissue being model outputs. Simulations were run to assess effects of animal characteristics on the transfer of PCBs to eggs. Laying rate proportionally influenced the PCB level of eggs and adipose tissue at steady state. Body fat diluted absorbed PCBs in the absence of laying and significantly influenced the decontamination rate of tissues during depuration after an exposure period. Application of the present model to actual exposure cases highlights its value in improving the support of risk management in livestock farming.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Modeling PCB transfer into hen eggs: Influence of physiological characteristics of the animal

Fournier

Martin

Travel

et al. 2014

Enviro Toxic and Chemistry

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“…, 2002), sheep (Ammoun et al. , 2006), chickens (Opdycke & Menzer, 1984), pigs (Sutherland et al. , 2005), and dogs (Paulson et al.…”

Section: Physiological Variables That Can Influence Drug Kineticsmentioning

confidence: 99%

Patient variation in veterinary medicine - Part II - Influence of physiological variables

Modrić

Martinez

2010

Journal of Veterinary Pharmacology and Therapeutics

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Modric, S., Martinez, M. Patient variation in veterinary medicine – Part II – Influence of physiological variables. J. vet. Pharmacol. Therap.34, 209–223. In veterinary medicine, the characterization of a drug’s pharmacokinetic properties is generally based upon data that are derived from studies that employ small groups of young healthy animals, often of a single breed. In Part I of the series, we focused on the potential influence of disease processes, stress, pregnancy and lactation on drug pharmacokinetics. In this Part II of the series, we consider other covariates, such as gender, heritable traits, age, body composition, and circadian rhythms. The impact of these factors with respect to predicting the relationship between dose and drug exposure characteristics within an animal population is illustrated through the use of Monte Carlo simulations. Ultimately, an appreciation of these potential influences will improve the prediction of situations when dose adjustments may be appropriate.

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“…It is well recognized that there exists breed (Opdycke & Menzer, 1984; Danielson & Taylor, 1993; Court et al. , 1999) and sex‐related differences (Cristofol et al ., 1998) in drug pharmacokinetics among veterinary species.…”

Section: Statisticsmentioning

confidence: 99%

“…It is well recognized that there exists breed (Opdycke & Menzer, 1984;Danielson & Taylor, 1993;Court et al, 1999) and sexrelated differences (Cristofol et al, 1998) in drug pharmacokinetics among veterinary species. However, to date, there is little if any evidence to support concerns regarding breed-by-formulation or gender-by-formulation interactions with veterinary pharmaceuticals.…”

Section: Expressed Viewsmentioning

confidence: 99%

Challenges associated with the evaluation of veterinary product bioequivalence: an AAVPT perspective

Martinez

Langston²,

Martín

et al. 2002

Vet Pharm & Therapeutics

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The Generic Animal Drug Patent Term Restoration Act (GADPTRA) enacted in 1988 provided the same benefits to animal drug products that were granted to human generic products. It has been over 13 years since the GADPTRA was enacted, and veterinary drug sponsors and regulators have gained enormous insight and experience into some of the unique challenges associated with the determination of product bioequivalence for veterinary dosage forms. Moreover, advances in information and technology have opened both new issues that must be addressed and new mechanisms for demonstrating product bioequivalence. While many aspects of the existing Center for Veterinary Medicine Bioequivalence Guidance continue to provide invaluable guidance to the animal drug industry, there are also aspects of this guidance that are being called into question. Therefore, during the 2001 annual meeting of the American Academy of Veterinary Pharmacology and Therapeutics, participants were asked to address issues and concerns associated with the evaluation of veterinary product bioequivalence. This manuscript provides a summary of the concerns and discussions that transpired.

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Pharmacokinetics of diflubenzuron in two types of chickens

Cited by 23 publications

References 20 publications

Modeling PCB transfer into hen eggs: Influence of physiological characteristics of the animal

Modeling PCB transfer into hen eggs: Influence of physiological characteristics of the animal

Patient variation in veterinary medicine - Part II - Influence of physiological variables

Challenges associated with the evaluation of veterinary product bioequivalence: an AAVPT perspective

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