Pharmacokinetics of dexmedetomidine during administration of vatinoxan in male neutered cats anesthetized with isoflurane

Effects of dopamine, norepinephrine or phenylephrine on the prevention of hypotension in isoflurane-anesthetized cats administered vatinoxan or vatinoxan and dexmedetomidine

“…Dexmedetomidine (Dexmedesed; Dechra Veterinary Products LLC, KS, USA) was diluted to 0.1 mg mL −1 using sterile 0.9% saline. Vatinoxan and dexmedetomidine were administered by target-controlled infusion as previously described, using previously published pharmacokinetic data obtained in anesthetized cats (Pypendop et al 2019(Pypendop et al , 2020a. The vatinoxan target plasma concentration (TPC) was 1 µg mL −1 and remained constant throughout the study.…”