“…CYP2C19 PMs have significantly higher concentrations of citalopram (Sindrup et al, 1993;Herrlin et al, 2003), fluoxetine , and sertraline (Wang et al, 2001). Citalopram (racemic and the active S-enantiomer) concentrations are ϳ1.7-fold higher in PMs at steady state (Sindrup et al, 1993;Herrlin et al, 2003), although no significant difference was seen after a single dose (Yu et al, 2003). The AUC of sertraline was 1.4-fold higher after a single dose in Chinese volunteers (Wang et al, 2001).…”