Pharmacokinetics of ciprofloxacin in eels by high-performance liquid chromatography with fluorescence detection

Guo, Liangqia; Xie, Zenghong; Lin, Xucong; Wu, Xiaoping; Qiu, Bin; Zhang, Yubin; You, Hainan

doi:10.1016/j.ab.2005.01.022

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…The T 1/2α values in muscle were 1.24, 12.05 and 8.60 h, respectively, for intramuscular administration, oral administration and bath treatment. The T 1/2α of CIP was also affected by administration regime in Japanese eel, Anguilla japonica , after oral administration and bath treatment, where the T 1/2α values were 0.10 and 0.02 h (Guo et al 2005); the drug was absorbed faster by bath treatment than by oral administration, which is in agreement with the present study. In contrast, Zhu et al (2006) found that there were no significant differences in the T 1/2α values (1.31 and 1.73 h) of florfenicol in the turtle after intramuscular and oral administration.…”

Section: Discussionsupporting

confidence: 91%

“…At present, most work on the pharmacokinetics of fluoroquinolones has focused on crucian carp (Ding et al 2006), Nile tilapia (Xu, Zhu, Wang, Deng & Zhang 2006) and eel (Guo, Xie, Lin, Wu, Qiu, Zhang, You & Chen 2005), while there have been few studies on crustaceans, including Chinese shrimp (Li, Li, Wang & Zhan 2006), E. sinensis (Yang, Liu & Yokoyama 2003; Tang, Yang, Zheng, Yu, Hu & Yu 2006; Wu, Meng, Zhu & Huang 2006), etc. All studies on E. sinensis adopt intramuscular administration; this practice could not reflect the actual residue level of ENR in production.…”

Section: Introductionmentioning

confidence: 99%

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Study on the pharmacokinetics of enrofloxacin in the Chinese mitten-handed crab,Eriocheir sinensis, after different administration regimes

Zhang

Yuan

et al. 2008

Aquaculture Research

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A pharmacokinetic study on enrofloxacin (ENR) following different administration regimes (i.e. intramuscular, oral and bath administrations) was carried out for the Chinese mitten‐handed crab (Eriocheir sinensis) at 17 °C water temperature. Muscle and hepatopancreas samples were collected at each sampling time of 1 and 10 min and 0.5, 1, 2, 8, 16, 24, 48, 72 and 168 h for intramuscular administration and 0.25, 0.5, 1, 2, 4, 6, 8, 12, 24, 48, 72 and 168 h for oral and bath administration. The levels of ENR and ciprofloxacin (CIP) were simultaneously determined (n=5) by high‐performance liquid chromatography. The results showed that similar absorption and elimination patterns of ENR level in muscle and hepatopancreas were observed for oral administration and bath treatment; however, the trend in ENR level changes in muscle and hepatopancreas after intramuscular administration was quite different from oral and bath treatments. Meanwhile, the level of ENR in hepatopancreas was much higher than that in muscle for the same administration regimes. The concentration–time data were analysed with the Practical Pharmacokinetics Program (3P97), and the kinetic profiles of ENR in the hepatopancreas and muscle conformed to two‐compartment models. The absorption and elimination of ENR in hepatopancreas for bath treatment were faster than those for oral and intramuscular administrations. However, the pattern was quite different in muscle. The fastest absorption and elimination of ENR in muscle were seen for intramuscular administration.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Study on the pharmacokinetics of enrofloxacin in the Chinese mitten-handed crab,Eriocheir sinensis, after different administration regimes

Zhang

Yuan

et al. 2008

Aquaculture Research

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“…The model was selected on the basis of the residual sum of squares and minimum Akaike's information criterion (AIC) value [14,15]. AIC is a criterion for selecting the best model among a number of candidate models, and the model that yields the smallest value of AIC is considered the best.…”

Section: Metabolic Kinetics Analysismentioning

confidence: 99%

Metabolic Kinetics of tert‐Butylhydroquinone and Its Metabolites in Rat Serum after Oral Administration by LC/ITMS

Huang

Niu

2008

Lipids

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Liquid chromatography-ion trap mass spectrometry (LC/ITMS) was employed for a metabolic kinetics study of tert-butylhydroquinone (TBHQ) and its metabolites in rat serum after oral administration. The mean serum concentration-time data of TBHQ and its four metabolites (M1-M4) in both male and female rats after oral administration of TBHQ at dosages of 7, 350 and 700 mg/kg were all best-fitted by a two-compartment model with first-order absorption. TBHQ was rapidly absorbed, distributed and metabolized. The metabolites were also distributed rapidly except M2, but eliminated more slowly than TBHQ. At the doses of 350 and 700 mg/kg, the total concentrations of TBHQ and its metabolites in serum were much higher for male than female rats during the metabolic process (P < 0.01). In addition, the serum concentrations of M1, M3 and M4 were all much higher for males than for females (P < 0.01) during the metabolic process, while no significant differences between male and female rats were found (P > 0.05) for TBHQ and M2, at the doses of 350 and 700 mg/kg. The exploratory assessment of dose proportionality for TBHQ and its metabolites by the power model indicated that the TBHQ exposure increased in a more-than-dose-proportional manner, but the exposures of the metabolites M1-M4 increased in a less-than-dose-proportional manner, across the dose of 7-700 mg/kg.

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“…Several analytical methods have been developed for analysis of FQs and ciprofloxacin (CPFX) (Fig. 1a) from biological matrices; these have been based on capillary zone electrophoresis [3][4][5][6] or high-performance liquid chromatography (HPLC) [7], mainly with fluorescence [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], ultraviolet [8,16,[25][26][27][28][29][30], chemiluminescence [6,31,32], or mass spectrometric (MS) [14,[33][34][35][36][37][38][39][40][41][42][43] detection. Non-routine techniques for FQ analysis, for example terbium(III)-sensitised luminescence [44,45]...…”

Section: Introductionmentioning

confidence: 99%

Analysis of ciprofloxacin in low- and high-fat milk by high-performance liquid chromatography-mass spectrometry

Pápai

Budai

Ludányi

et al. 2010

Acta Chromatographica

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The quantitative analysis of antibiotics in different matrices is of increasing importance in in vitro studies of food-drug interactions in the drug-development process. Our objective was to develop a new, rapid and simple solid-phase extraction method without protein precipitation followed by high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) for analysis of ciprofloxacin in lowand high-fat milk. The HPLC-MS method (a single-quadrupole mass spectrometer equipped with an electrospray ion source was used as detector) was validated using a quinolone derivative, aripiprazole, as internal standard. A C 8 column and gradient elution with 0.02 M ammonium acetate solution (pH 2.5) and acetonitrile mixtures (flow rate 0.5 mL min −1 ) were used for HPLC separation. Various modes of detection (diode-array detection and MS detection in scanning and selected-ion monitoring modes) were compared for selectivity and sensitivity of quantitative analysis of ciprofloxacin. Use of selected-ion monitoring resulted in a 1600:1 signal-to-noise ratio which can be successfully applied to milk matrices resulting in a lower limit of detection of 0.4 ng mL −1 and a lower limit of quantification of 4.0 ng mL −1 . Recovery was 99.06 ± 0.15 and 98.57 ± 0.14% for low-and high-fat milk, respectively. The method enables analysis of the free, biologically available, amount of ciprofloxacin in in vitro simulation of milk-ciprofloxacin interaction studies.

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Pharmacokinetics of ciprofloxacin in eels by high-performance liquid chromatography with fluorescence detection

Cited by 10 publications

References 21 publications

Study on the pharmacokinetics of enrofloxacin in the Chinese mitten-handed crab,Eriocheir sinensis, after different administration regimes

Study on the pharmacokinetics of enrofloxacin in the Chinese mitten-handed crab,Eriocheir sinensis, after different administration regimes

Metabolic Kinetics of tert‐Butylhydroquinone and Its Metabolites in Rat Serum after Oral Administration by LC/ITMS

Analysis of ciprofloxacin in low- and high-fat milk by high-performance liquid chromatography-mass spectrometry

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