“…On one hand, there is a species difference in elimination pathways of digoxin and β‐methyldigoxin between rats and humans. For example, more than 30% of dose of these cardiac glycosides is recovered in urine within 24 h in humans 41–43. Thus, there may be some differences in the extent of hepatic distribution of these cardiac glycosides between rats and humans, although digoxin is recognized by human OATP8 (SLC21A8) and OATP8 is localized to the sinusoidal membrane of hepatocytes in humans, as well as in rats 44,45.…”