Pharmacokinetics of Beclomethasone Dipropionate Delivered by Breath-Actuated Inhaler and Metered-Dose Inhaler in Healthy Subjects

Abstract

Systemic availability of 17-BMP following administration of beclomethasone dipropionate was bioequivalent between BAI and MDI at the 320-mcg dose, and approximately dose proportional at the 160- and 320-mcg doses using the BAI.

Endotracheal Aerosolization Device for Laboratory Investigation of Pulmonary Delivery of Nanoparticle Suspensions: In Vitro and in Vivo Validation

“…20 Metered-dose inhalation is an actuationdependent administration method, where nanoparticle suspensions are delivered with the propellant on actuation. 21 However, actuation-inhalation-coordination 22 cannot be assured in animals, which leads to exhalation or escape of the delivered nanoparticle suspensions and results in a low pulmonary deposition. For intratracheal instillation, the trachea is exposed and nanoparticle suspensions are directly instilled into the respiratory tract.…”

“…The administered nanoparticle suspensions may be swallowed and transported into the gastrointestinal tract after oropharyngeal aspiration, which reduces the amount of nanoparticle suspensions that enter the pulmonary region . Metered-dose inhalation is an actuation-dependent administration method, where nanoparticle suspensions are delivered with the propellant on actuation . However, actuation-inhalation-coordination cannot be assured in animals, which leads to exhalation or escape of the delivered nanoparticle suspensions and results in a low pulmonary deposition.…”