Pharmacokinetics of Azlocillin in Persons with Normal and Impaired Renal Functions

Fiegel, P.; Becker, Klaus

doi:10.1128/aac.14.3.288

Cited by 23 publications

(7 citation statements)

References 6 publications

(3 reference statements)

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“…The ty2 p va lues were in the same range as described in previous studies in patients without addi tional antibiotic treatment [6,11,13]. One important exception in our investigation was patient No.…”

Section: Discussionsupporting

confidence: 54%

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Azlocillin Serum Levels on Repetitive Dosage in Patients with Normal and Abnormal Renal Function

Wenk¹,

Follath²

1986

Chemotherapy

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Azlocillin serum concentrations were followed in 9 severely ill patients with various degrees of renal dysfunction after single and repetitive dosage. All patients were treated concomitantly with a cephalosporin and/or an aminoglycoside antibiotic. Elimination halflives (t_½β) were highly variable (62–1,194 min), but no significant increase occurred in patients with stable renal function during repetitive dosage due to previously described nonlinear pharmacokinetic behavior of azlocillin. However, drug accumulation was observed in patients with deterioration of renal and hepatic function. The rise in drug accumulation can be disproportionally high if both routes of elimination are affected. In such cases, careful dosage adjustment of azlocillin is required to avoid toxic side effects.

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Section: Discussionsupporting

confidence: 54%

“…Serum levels remained well above the av erage reported MIC limits for P. aerugin osa strains [7,15] for at least 6 h in all pa tients. The corresponding elimination half-life varied between 62 and 313 min in [5][6][7][8][9]. The difference between the mean t'/ip was statistically not significant (paired t test).…”

Section: Resultsmentioning

confidence: 99%

Azlocillin Serum Levels on Repetitive Dosage in Patients with Normal and Abnormal Renal Function

Wenk¹,

Follath²

1986

Chemotherapy

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“…In spite of the lower mezlocillin elimination in urine and the considerable decrease with increasing renal insufficiency, therapeutic urine levels are obtained over wide ranges of functional loss. quite similar to that of azlocillin (6,12 aValues indicate mean ± standard deviation; four patients in each dialysis group. (Fig.…”

Section: Resultsmentioning

confidence: 99%

Effects of impaired renal function, hemodialysis, and peritoneal dialysis on the pharmacokinetics of mezlocillin

Kampf¹,

Schurig²,

K³

et al. 1980

Antimicrob Agents Chemother

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The pharmacokinetics of mezlocillin were examined in 8 patients with normal renal function (inulin clearance, >80 ml/min per 1.73 m2), 32 patients with moderately reduced renal function (inulin clearance, 80 to 5 ml/min per 1.73 m2), and 12 patients maintained by hemodialysis or peritoneal dialysis because of severely impaired renal function. A single dose of 60 mg of mezlocillin per kg of body weight was infused intravenously over 30 min. Antibiotic concentrations in plasma, urine, and dialysate were determined by the agar diffusion technique. The half-life of mezlocillin increased with decreasing renal function from an average of 53 min in subjects with normal function to 165 min in oligoanuric patients. The urinary recovery of this drug in 24 h decreased from 65% at a glomerular fitration rate of 92 ml/min to 7.6% at a glomerular filtration rate of 6.7 ml/min. Volume of distribution was not changed by the renal insufficiency, amounting on the average to 22.5% of body weight. Intermittent hemodialysis or peritoneal dialysis contributed to only a minor degree to the 24-h mezlocillin kinetics. The pharmacokinetic properties of mezlocillin permit a normal dosage over wide ranges of renal insufficiency; however, when the glomerular filtration rate is below 10 ml/min, the dosage interval should be increased from 8 to 12 h.

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“…In patients with varying degrees of renal insufficiency, FIEGEL and BECKER (1978) found a linear relationship between inulin clearance rate and serum half-life on a log-log scale. In patients with end-stage renal disease, mean serum half-life is about 2 h on dialysis and twice that off dialysis.…”

Section: Azlocillinmentioning

confidence: 92%

Pharmacokinetics of β-Lactam Antibiotics

Kwan¹

1983

Antibiotics

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Pharmacokinetics of Azlocillin in Persons with Normal and Impaired Renal Functions

Cited by 23 publications

References 6 publications

Azlocillin Serum Levels on Repetitive Dosage in Patients with Normal and Abnormal Renal Function

Azlocillin Serum Levels on Repetitive Dosage in Patients with Normal and Abnormal Renal Function

Effects of impaired renal function, hemodialysis, and peritoneal dialysis on the pharmacokinetics of mezlocillin

Pharmacokinetics of β-Lactam Antibiotics

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