Pharmacokinetics of amoxicillin trihydrate in cultured olive flounder (<i>Paralichthys olivaceus</i>)

Seo, Jung Soo; Jeon, Eun Ji; Jung, Sung Hee; Park, Myoung Ae; Kim, Na Young

doi:10.1111/jvp.12155

Cited by 8 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Parenteral administration of drugs in culture fish is mostly limited to specific agents like vaccines, reproduction controllers or anaesthetics due to technical difficulty and high labour costs (Black, 2000). In recent years, however, the application of some injectable drugs has been found feasible when they were administered intramuscularly in Korean culture farms, particularly for olive flounder (Lee & Park, 2015; Lim et al., 2017; Seo et al., 2015). This fish species is generally calm and can easily be handled without excess stress during injections.…”

Section: Discussionmentioning

confidence: 99%

Estimation of pharmacological properties of ceftiofur, an injectable cephalosporin antibiotic, for treatment of streptococcosis in cultured olive flounderParalichthys olivaceus

et al. 2020

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Estimation of pharmacological properties of ceftiofur, an injectable cephalosporin antibiotic, for treatment of streptococcosis in cultured olive flounderParalichthys olivaceus

et al. 2020

View full text Add to dashboard Cite

“…However, Seo et al . () reported that a two‐compartment model best represented the relationship between plasma concentration and the time after i.m. administration of amoxicillin trihydrate in olive flounder.…”

Section: Discussionmentioning

confidence: 99%

“…Seo et al . () reported the pharmacokinetics of amoxicillin trihydrate in olive flounder following oral, i.m., and intravenous (i.v.) administrations.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of amoxicillin sodium against streptococcosis in cultured olive flounder Paralichthys olivaceus and its pharmacokinetics

Lim

Jung

et al. 2016

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

The efficacy of amoxicillin sodium for controlling field and experimental Streptococcus iniae and S. parauberis infections in olive flounder (Paralichthys olivaceus) was evaluated after a single intramuscular administration. Furthermore, the minimal inhibitory concentrations (MIC) against 21 Streptococcus strains were determined. In addition, the pharmacokinetics and residue depletion in olive flounder were investigated. Single intramuscular doses of amoxicillin sodium at 20, 40, 80, and 160 mg/kg b.w. fish significantly reduced cumulative mortality rates to 18.8-31.3% (P < 0.05) for S. iniae and to 5.0-15.0% (P < 0.01) for S. parauberis, whereas the S. iniae- and S. parauberis-infected positive control groups showed cumulative mortality rates of 68.8% and 60.0%, respectively. In a S. parauberis outbreak, amoxicillin sodium reduced the cumulative mortality rate to 7.5% and 4.8% at 20 and 40 mg/kg b.w. fish, respectively, whereas that of the untreated control group was 35.2%. Peak plasma concentrations (C ) following a single intramuscular dose of 40 and 80 mg/kg b.w. fish were 62.64 (T , 1.59 h) and 87.61 (T , 3.02 h) μg/mL, respectively, with large AUC /MIC and C /MIC ratios, and sufficient T > MIC (time for maintaining plasma drug concentration greater than MICs) for S. iniae and S. parauberis. The estimated withdrawal period of amoxicillin sodium from muscle of olive flounder was about 8 days at 40 mg/kg b.w. fish (at 22 ± 1 °C). These results demonstrated a single intramuscular administration of amoxicillin sodium to be effective against streptococcosis in olive flounder.

show abstract

“…Pharmaceutics 2023, 15, 1153 2 of 8 Seo et al [6] determined the PK of AMOX in olive flounder after a single IM injection of trihydrate salt.…”

Section: Introductionmentioning

confidence: 99%

Influence of Intramuscular Injection Sites on Pharmacokinetics of Amoxicillin in Olive Flounder (Paralichthys olivaceus) and Its Implication for Antibacterial Efficacy

et al. 2023

View full text Add to dashboard Cite

This study aimed to investigate the effects of different injection sites, including dorsal, cheek, and pectoral fin muscles, on the pharmacological properties of amoxicillin (AMOX) in olive flounder (Paralichthys olivaceus) after a single intramuscular (IM) injection of 40 mg/kg. The AMOX concentration was measured using high-performance liquid chromatography-tandem mass spectrometry, followed by a non-compartmental model analysis. The peak serum concentrations (Cmax) achieved 3 h after dorsal, cheek, and pectoral fin IM injections were 202.79, 203.96, and 229.59 μg/mL, respectively. The area under the concentration-time curve (AUC) was 1697.23, 2006.71, and 1846.61 µg/mL·h, respectively. The terminal half-life (t1/2λZ) was prolonged for cheek and pectoral fin IM injections (10.12 and 10.33 h, respectively) compared to dorsal IM injection (8.89 h). In the pharmacokinetic-pharmacodynamic analysis, a higher T > minimum inhibitory concentration (MIC) and AUC/MIC values were observed after AMOX was injected into the cheek and pectoral fin muscles compared to the dorsal muscle. Muscle residue depletion was below the maximum residue level from day 7 after IM injection at all three sites. These findings suggest that the cheek and pectoral fin sites provide advantages regarding systemic drug exposure and prolonged action compared with the dorsal site.

show abstract

Pharmacokinetics of amoxicillin trihydrate in cultured olive flounder (Paralichthys olivaceus)

Cited by 8 publications

References 25 publications

Estimation of pharmacological properties of ceftiofur, an injectable cephalosporin antibiotic, for treatment of streptococcosis in cultured olive flounderParalichthys olivaceus

Estimation of pharmacological properties of ceftiofur, an injectable cephalosporin antibiotic, for treatment of streptococcosis in cultured olive flounderParalichthys olivaceus

The efficacy of amoxicillin sodium against streptococcosis in cultured olive flounder Paralichthys olivaceus and its pharmacokinetics

Influence of Intramuscular Injection Sites on Pharmacokinetics of Amoxicillin in Olive Flounder (Paralichthys olivaceus) and Its Implication for Antibacterial Efficacy

Contact Info

Product

Resources

About