“…with blood, mucus, other cells) that can lead to overestimation of drug concentrations. In the author's pharmacokinetics studies of 1 g azithromycin in rectal 37 and endocervical tissue, 68 the sampling methods were unable to differentiate both between intracellular and extracellular space and although the studies were able to report high concentrations of azithromycin, they were unable to report whether it was in the appropriate compartments for chlamydia infection. Further, the studies were unable to differentiate between azithromycin in mucus, blood or cervical/rectal epithelial cellular tissue.…”