Pharmacokinetics of 5-fluorouracil and its catabolites determined by 19F nuclear magnetic resonance spectroscopy for a patient on chronic hemodialysis

Pharmacodynamic Study of the Saltz Regimen for Metastatic Colorectal Cancer in a Hemodialyzed Patient

“…Even though combined chemotherapy, such as IFL or FOLFOX, is more efficient against colorectal cancer than a single agent, no paper exists regarding its use in HD patients. We considered modified IFL to be the first-line choice for the present patient because CPT-11 [7] and 5-FU [11] could be given safely, although there were little relevant data. In fact, the dose of chemotherapy for HD patients is determined by each doctor's 'allowance'.…”

Fluorine-19 or phosphorus-31 NMR spectroscopy: A suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs

“…For 19 F NMR analyses, FBEN in D 2 O is employed by Martino's group [34][35][36][37] and Kamm et al [38,39], C 6 F 6 and, since 1990, 1,2-difluorotetrachloroethane (DFTCE) in benzene-d6 by Hull's group [40][41][42][43][44][45], NaF in D 2 O by Wyrwicz and coworkers [46]. Hexachlorocyclotriphosphazene (HCCP) in toluene-d8 [23,24] then MPA in D 2 O [20] are utilised by Martino's group for 31 P NMR analyses.…”

“…Hull's group determines concentrations of fluorinecontaining compounds in urine, plasma and tissue extracts using Bruker AM-500 or AM-300 SWB spectrometers ( 19 F resonance frequencies 470.6 and 282.4 MHz, respectively) with 5 or 10 mm diameter tubes without 1 H decoupling, which avoids complications owing to NOE signal enhancements [40,41,43].…”

Monitoring fluoropyrimidine metabolism in solid tumors with in vivo 19F magnetic resonance spectroscopy

“…When a treatment protocol leads to high plasma concentrations of FBAL, then the adducts N-carboxy-FBAL and FBAL glucoside can be detected (in equilibrium with FBAL). High levels of FBAL have been associated with neurotoxicity and cardiotoxicity, possibly due to its conversion into ␣-fluoro-␤-hydroxypropionate (FHPA) and fluoroacetate (FAC) [20][21][22]. Finally, fluoride (F − ) can be released from FBAL via enzymatic reactions, which are particularly efficient in rat liver [23].…”