Pharmacokinetics in pulmonary epithelial lining fluid and plasma of ampicillin and pivampicillin administered to horses

Winther, Lotte; Baptiste, Keith E.; Friis, Christian

doi:10.1016/j.rvsc.2010.11.001

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…This ratio was found to be 1.00 when oral pivampicillin was administered. In a study conducted in horses, orally administered pivampicillin was emphasized to provide clinically significant drug concentrations in the PELF for at least 12 hours (Winther et al, 2012). Bacampicillin Bacampicillin is the acid-stable ethoxycarbonyloxymethyl ester of ampicillin.…”

Section: Ampicillin Estersmentioning

confidence: 99%

The bioavailability of ampicillins in some animals

Güzelaydın,

Yıldırım

2024

Journal of Istanbul Veterinary Sciences

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Ampicillin, a partially synthetic derivative of penicillin, has been widely used in both human and veterinary medicine for a long time. As a result of its limited ability to be absorbed into the bloodstream when taken orally by humans, precursor chemicals such bakampicillin, pivampicillin, and talampicillin have been created. Although ampicillin is widely used in veterinary treatment practice, the applications of ampicillin esters in animals have not gone beyond scientific trials and have not found widespread use. Since there are not many antibiotic options authorized for use in poultry, in our review, the pharmacokinetic properties of ampicillins, especially oral bioavailability, in some animal species will be mentioned and the need for studies that will examine the bioavailability of pre-ampicillins will be emphasized.

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Section: Ampicillin Estersmentioning

confidence: 99%

The bioavailability of ampicillins in some animals

Güzelaydın,

Yıldırım

2024

Journal of Istanbul Veterinary Sciences

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“…Tubes with absorbent disc/cotton swab Absorbent discs or cotton swabs have been used to sample bronchial secretions/ PELF in calves (Halstead et al, 1992;Friis, 1993;McKellar et al, 1999;Sarasola et al, 2002), pigs (Agerso and Friis, 1998) and in horses (Godber et al, 1995;Winther et al, 2010aWinther et al, , b, 2011Winther et al, , 2012. The technique has been applied to both conscious and anaesthetised animals as a blind placement of a guarding tube into the distal bronchi, until wedging, and then passing a sampling disc/cotton swab for 1-2 min before withdrawal.…”

Section: Bronchoalveolar Lavagementioning

confidence: 99%

“…Two b-lactam drugs, including ampicillin (Winther et al, 2012) and cefquinome (Winther et al, 2011), were measured in plasma and PELF using HPLC. Both studies demonstrated PELF exposure of approximately one-third of plasma exposure over the sampling period following IV administration.…”

Section: Absorbent Discs/cotton Swabsmentioning

confidence: 99%

Antimicrobial drug concentrations and sampling techniques in the equine lung

Winther

2012

The Veterinary Journal

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“…Bronchoalveolar lavage is widely used for collecting samples from the respiratory tract [ 19 ], and it is also commonly used to collect pulmonary epithelial lining fluid (PELF) to study the PK of drugs in pigs [ 20 ]. The bronchoalveolar lavage has a large advantage in taking pulmonary samples, as compared to homogenized lung tissue [ 21 ], cotton swab [ 22 ], microdialysis [ 23 ], imaging techniques, and other methods [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

PK-PD Modeling and Optimal Dosing Regimen of Acetylkitasamycin against Streptococcus suis in Piglets

Huang¹,

Mao²,

Huang³

et al. 2022

Antibiotics

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Streptococcus suis (S. suis) causes severe respiratory diseases in pigs and is also an important pathogen causing hidden dangers to public health and safety. Acetylkitasamycin is a new macrolide agent that has shown good activity to Gram-positive cocci such as Streptococcus. The purpose of this study was to perform pharmacokinetic–pharmacodynamic (PK-PD) modeling to formulate a dosing regimen of acetylkitasamycin for treatment of S. suis and to decrease the emergence of acetylkitasamycin-resistant S. suis. The minimal inhibitory concentration (MIC) of 110 S. suis isolates was determined by broth micro dilution method. The MIC50 of the 55 sensitive S. suis isolates was 1.21 μg/mL. The strain HB1607 with MIC close to MIC50 and high pathogenicity was used for the PK-PD experiments. The MIC and MBC of HB1607 in both MH broth and pulmonary epithelial lining fluid (PELF) was 1 and 2 μg/mL, respectively. The liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was used to determine the concentration change of acetylkitasamycin in piglet plasma and PELF after intragastric administration of a single dose of 50 mg/kg b.w. acetylkitasamycin. The PK parameters were calculated by WinNolin software. The PK data showed that the maximum concentration (Cmax), peak time (Tmax), and area under the concentration–time curve (AUC) were 9.84 ± 0.39 μg/mL, 4.27 ± 0.19 h and 248.58 ± 21.17 h·μg/mL, respectively. Integration of the in vivo PK data and ex vivo PD data, an inhibition sigmoid Emax equation was established. The dosing regimen of acetylkitasamycin for the treatment S. suis infection established as 33.12 mg/kg b.w. every 12 h for 3 days. This study provided a reasonable dosing regimen for a new drug used in clinical treatment, which can effectively be used to treat S. suis infection and slow down the generation of drug resistance.

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Pharmacokinetics in pulmonary epithelial lining fluid and plasma of ampicillin and pivampicillin administered to horses

Cited by 8 publications

References 22 publications

The bioavailability of ampicillins in some animals

The bioavailability of ampicillins in some animals

Antimicrobial drug concentrations and sampling techniques in the equine lung

PK-PD Modeling and Optimal Dosing Regimen of Acetylkitasamycin against Streptococcus suis in Piglets

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