Pharmacokinetics, disposition, and plasma concentrations of dimethyl sulfoxide (DMSO) in the horse following topical, oral, and intravenous administration

Abstract

Compartmental models were used to investigate the pharmacokinetics of intravenous (i.v.), oral (p.o.), and topical (TOP) administration of dimethyl sulfoxide (DMSO). The plasma concentration-time curve following a 15-min i.v. infusion of DMSO was described by a two-compartment model. Median and range of alpha (t ) and beta (t ) half-lives were 0.029 (0.026-0.093) and 14.1 (6.6-16.4) hr, respectively. Plasma concentration-time curves of DMSO following p.o. and TOP administration were best described by one-compartment absorption and elimination models. Following the p.o. administration, median absorption (t ) and elimination (t ) half-lives were 0.15 (0.01-0.77) and 15.5 (8.5-25.2) hr, respectively. The plasma concentrations of DMSO were 47.4-129.9 μg/ml, occurring between 15 min and 4 hr. The fractional absorption (F) during a 24-hr period was 47.4 (22.7-98.1)%. Following TOP administrations, the median t and t were 1.2 (0.49-2.3) and 4.5 (2.1-11.0) hr, respectively. Plasma concentrations were 1.2-8.2 μg/ml occurring at 2-4 hr. Fractional absorption following TOP administration was 0.48 (0.315-4.4)% of the dose administered. Clearance (Cl) of DMSO following the i.v. administration was 3.2 (2.2-6.7) ml hr kg . The corrected clearances (Cl ) for p.o. and TOP administrations were 2.9 (1.1-5.5) and 4.5 (0.52-18.2) ml hr kg .

Fish oil attenuated dystrophic muscle markers of inflammation via FFA1 and FFA4 in the mdx mouse model of DMD

“…DMSO decreased total CK (Figure 1), an effect possibly related to its anti-inflammatory activity (Soma et al, 2018) and demonstrated here by a reduction in the levels of NFkB and TNF-α (DIA and heart) and IL-1β (DIA; Figure 3).…”

“…; n = 5) followed by omega‐3 oil (FDC Vitamins, Inc., Miami, FL; Omega‐3 EPA 1000 mg; 300 mg/kg body weight; 0.1 ml by gavage), 3 days per week for 1 month (beginning at 3 months of age), on alternate days. In one group, mdx mice ( n = 5) received the vehicle (DMSO; 99.9%, Sigma; mdx ‐DMSO) by the same period, route and volume and served as a control for potential anti‐inflammatory effects of DMSO, as previously reported (Soma, Robinson, You, Boston, & Rudy, 2018).…”

Effect of sirolimus on insulin dynamics in horses

“…Sirolimus whole‐blood concentration vs time data were fit to a compartmental model using nonlinear least squares regression via a mathematical modeling software package (WinSAAM, University of Pennsylvania, Kennett Square, Pennsylvania, USA) as performed previously. 26 , 27 , 28 Visual inspection of the IV‐time profile of blood sirolimus suggested that the data fit a 2‐compartment model. The best fit was obtained by minimizing fractional SD of the micro‐rate constants and by convergence of the predicted and observed plasma concentration curves.…”

Autocuidado em diabetes

“…O DMSO foi o diluente utilizado para preparo dos antagonistas GW1100 e AH7614. A literatura sugere que este diluente pode apresentar efeito anti-inflamatório (SOMA et al, 2018), fato que justifica a necessidade de um grupo tratado apenas com DMSO para observação e normalização dos efeitos que observamos.…”

“…e em adipócitos(EKBERG et al, 2016;MUNKARAH et al, 2016), sendo escassos os estudos no tecido muscular. Não obstante, na atualidade ainda não há consenso acerca do uso do DMSO em tratamentos em que necessitamos de veículo com alta solubilidade, sendo que alguns autores reforçam cautela para seu uso devido sua toxicidade(PETERSON et al, 2011) e efeito anti-inflamatório(SOMA et al, 2018). Ω3, o que nos sugere que os antagonistas empregados foram eficazes no bloqueio dos receptores GPR40 e GPR120, impedindo a ligação do Ω3 e, consequentemente, bloqueando o efeito anti-inflamatório.…”