2021
DOI: 10.21203/rs.3.rs-1085481/v1
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Pharmacokinetics, Bioavailability and Tissue Distribution of Chitobiose and Chitotriose in Rats

Abstract: Chitooligosaccharides (COSs) have various physiological activities and broad application prospects; however, their pharmacokinetics and tissue distribution remain unclear. In this study, a sensitive and selective ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method for determining chitobiose (COS 2) and chitotriose (COS 3) in rat serum and tissues was developed. This method was successfully validated based on FDA guidelines in terms of selectivity, calibration curves (lower limit of quan… Show more

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