1993
DOI: 10.1007/bf03259600
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Pharmacokinetics and Tissue Penetration of a Single Dose of Netilmicin as Antibiotic Prophylaxis in Colorectal Surgery

Abstract: SummaryThe pharmacokinetics, serum levels and tissue penetration of netilmicin were studied after a single intravenous injection of 6 mg/kg. 13 patients scheduled for elective colorectal surgery and for antibiotic prophylaxis were given a combination of netilmicin and a single dose of ornidazole (1000mg intravenously). Mean maximal (10 minutes) and last determined (24-hour) netilmicin serum levels were 24.4 ± 3.4 and 0.9 ± 0.5 mg/L, respectively. The ,8-phase elimination halflife was 413 ± 68 minutes, and the … Show more

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“…The other derivative of hydroquinone is deoxyarbutin (dA) that has more effective and safe clinically than arbutin to therapy hyperpigmentation. dA is second generation derivatives of hydroquinone [74]. dA is less cytotoxic than the others hydroquinone derivatives.…”
Section: Introductionmentioning
confidence: 99%
“…The other derivative of hydroquinone is deoxyarbutin (dA) that has more effective and safe clinically than arbutin to therapy hyperpigmentation. dA is second generation derivatives of hydroquinone [74]. dA is less cytotoxic than the others hydroquinone derivatives.…”
Section: Introductionmentioning
confidence: 99%