Pharmacokinetics and Tissue Distribution of Oxidized and Reduced Coenzyme Q10 Upon Intravenous Administration

Kalenikova, E. I.; Gorodetskaya, E. A.; Obolenskaya, O. N.; Shapavo, N. S.; Медведев, О. С.

doi:10.1007/s11094-021-02471-4

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…The pharmacokinetics of this new drug of ubiquinol was studied in comparison with ubiquinone, both forms having a similar excipient composition [65]. Both kinetic curves were found to be biphasic, with a comparable initial decrease rate in plasma concentration during the first hours after injection.…”

Section: Results Of Intravenous Coenzyme Q10 Administration In Experi...mentioning

confidence: 99%

“…Notably, the total CoQ10 amount accumulating in the liver remained consistent regardless of administration in oxidized or reduced form. The accumulation and subsequent secretion of CoQ10 into the blood via lipoproteins might contribute to its sustained elevated concentration levels in plasma and tissues over time [65].…”

Section: Results Of Intravenous Coenzyme Q10 Administration In Experi...mentioning

confidence: 99%

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Prospects of Intravenous CoenzymeQ10 Administration in Emergency Ischemic Conditions

Kalenikova,

Gorodetskaya,

Povarova

et al. 2023

Preprint

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Coenzyme CoQ10 (CoQ10) is an endogenous lipid-soluble antioxidant that effectively protects lipids, proteins and DNA from oxidation due to its ability to undergo redox transitions between oxidized and reduced forms. Various oxidative stress-associated infectious and somatic diseases have been observed to disrupt the balance of CoQ10 concentration in tissues. As a high molecular weight polar lipophilic compound, CoQ10 exhibits very limited oral bioavailability, which restrains its therapeutic potential. Nevertheless, numerous studies have confirmed the clinical efficacy of CoQ10 therapy through the oral administration of high doses over extended time periods. Experimental studies have demonstrated that in emergency situations, intravenous administration of both oxidized and reduced forms CoQ10 leads to a rapid increase in its concentration in organ tissues, offering protection in ischemic conditions for organ tissues. This suggests that the cardio- and neuroprotective efficacy of intravenously administered CoQ10 forms could present new opportunities in treating acute ischemic conditions. Based on these findings, the review provides reasoning supporting further research and implementation of CoQ10 dosage forms for intravenous administration in emergency situations into clinical practice.

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Section: Results Of Intravenous Coenzyme Q10 Administration In Experi...mentioning

confidence: 99%

Section: Results Of Intravenous Coenzyme Q10 Administration In Experi...mentioning

confidence: 99%

Prospects of Intravenous CoenzymeQ10 Administration in Emergency Ischemic Conditions

Kalenikova,

Gorodetskaya,

Povarova

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions

Kalenikova,

Gorodetskaya,

Povarova

et al. 2024

Life

View full text Add to dashboard Cite

Coenzyme CoQ10 (CoQ10) is an endogenous lipid-soluble antioxidant that effectively protects lipids, proteins, and DNA from oxidation due to its ability to undergo redox transitions between oxidized and reduced forms. Various oxidative stress-associated infectious and somatic diseases have been observed to disrupt the balance of CoQ10 concentration in tissues. As a high molecular weight polar lipophilic compound, CoQ10 exhibits very limited oral bioavailability, which restrains its therapeutic potential. Nevertheless, numerous studies have confirmed the clinical efficacy of CoQ10 therapy through oral administration of high doses over extended time periods. Experimental studies have demonstrated that in emergency situations, intravenous administration of both oxidized and reduced-form CoQ10 leads to a rapid increase in its concentration in organ tissues, offering protection for organ tissues in ischemic conditions. This suggests that the cardio- and neuroprotective efficacy of intravenously administered CoQ10 forms could present new opportunities in treating acute ischemic conditions. Based on these findings, the review provides reasoning supporting further research and implementation of CoQ10 dosage forms for intravenous administration in emergency situations into clinical practice.

show abstract

Pharmacokinetics and Tissue Distribution of Oxidized and Reduced Coenzyme Q10 Upon Intravenous Administration

Cited by 2 publications

References 20 publications

Prospects of Intravenous CoenzymeQ10 Administration in Emergency Ischemic Conditions

Prospects of Intravenous CoenzymeQ10 Administration in Emergency Ischemic Conditions

Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions

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