Pharmacokinetics and tissue distribution of oxytetracycline in carp, <i>Cyprinus carpio</i> L., following different routes of administration

Grondel, J.L.; Nouws, J. F. M.; Jong, Marion de; Schutte, A. R.; Driessens, F. C. M.

doi:10.1111/j.1365-2761.1987.tb01057.x

Cited by 107 publications

(61 citation statements)

References 14 publications

(12 reference statements)

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“…In man and mammals there is no indication of ciprofloxacin accumulation in specific tissues, and it is just as unlikely in fish. It is noteworthy that in catfish the extent of central compartment (VI) for ciprofloxacin (VI: 2.44 litre/kg) was 2 to 3 times larger than for carp; the same was observed for OTC (8).…”

Section: Sampling and Analysismentioning

confidence: 69%

“…The opposite was observed for the pharmacokinetics of oxytetracycline (OTC) in carp and catfish. Accumulation of OTC occurred in the carp (especially bones, pronephros and scales), but was limited in catfish revealing a smaller distribution volume in the latter species (7,8). In man and mammals there is no indication of ciprofloxacin accumulation in specific tissues, and it is just as unlikely in fish.…”

Section: Sampling and Analysismentioning

confidence: 96%

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Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow trout

Nouws

Grondel

Schutte

et al. 1988

Veterinary Quarterly

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SUMMARY The plasma disposition of ciprofloxacin was studied in carp, African catfish and trout after intravenous (IV) and intramuscular (IM) administration at a dose rate of 15 mg/ kg. Pharmacokinetic analysis of IV data showed that ciprofloxacin was well distributed (distribution volume V area): 3.08 -5.59 litre/kg) and exhibited a similar elimination half-life of about 14 h in these 3 fish species. After IM administration to carp and trout a rapid absorption was noticed; the maximum ciprofloxacin plasma concentrations (mean: 3.49 and 2.37 pg/ml, respectively), were achieved within I h after injection. At the dose level applied, ciprofloxacin has potential therapeutic value for 2-5 days especially against gram-negative bacterial fish pathogens.

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Section: Sampling and Analysismentioning

confidence: 69%

Section: Sampling and Analysismentioning

confidence: 96%

Pharmacokinetics of ciprofloxacin in carp, African catfish and rainbow trout

Nouws

Grondel

Schutte

et al. 1988

Veterinary Quarterly

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“…The OTC residues were reduced >98% by the acid treatment with HCl. It is known that OTC forms complexes with di-cation, such as Ca 2+ and Mg 2+ , in hard tissues of fish (Grondel et al, 1987;Jacobsen, 1989;Rogstad et al, 1991;Namdari et al, 1996;Malvisi et al, 1996;Maruyama and Uno, 1997). In our previous works, Ca-tetracycline chelates accumulated in shrimp shells and were shown to be considerably stable (Uno et al, 2006a).…”

Section: Chitin Yields From Carapace and Shellmentioning

confidence: 91%

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Uno¹,

Higashimoto²,

Chaweepack³

et al. 2012

Turk. J. Fish. Aquat. Sci.

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The present study examined the influences of industrial chitin extraction processes on the residual oxytetracycline (OTC) and oxolinic acid (OA) in shrimp carapaces and shells. The drugs were orally administered by catheter to the kuruma shrimp (Penaeus japonicus) and vannamei shrimp (Penaeus vannamei). The shrimps were sampled at 6-h post-dosing and their carapaces and shells were collected and used as raw material in the chitin extraction. Residual OTC levels in raw materials were 9 -18 fold higher than the maximum residue limit (MRL) (0.2 µg/g). The residual OTC was reduced 10 -30% by washing treatment. By the acid treatment with HCl, the OTC residues were reduced >98%. The deproteinized material contained negligible levels of OTC. Residual OA levels in raw materials was much higher (134 -376 fold) than the MRL (0.03 µg/g). The residual OA was reduced considerably (34 -68%) by washing treatment. By the demineralization, the residual OA could not be detected in both shrimp carapaces, while the levels of OA residues were determined more than MRL in shells. In the deproteinized materials, no residual OA were detected. Finally, residual OTC and OA could not be detected in the chitin materials for both shrimps.

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“…Possible sources are excess food pellets due to overfeeding, small drug-containing feed particles and drug-containing faeces due to incomplete absorption of the drugs in the fish intestine (Cravedi et al 1987, Grondel et al 1987, Hustvedt et al 1991. Since observations using underwater cameras indicate that wild fish usually do not eat faeces (J. E. Fosseidengen pers.…”

Section: Introductionmentioning

confidence: 99%