Pharmacokinetics and the active metabolite of enrofloxacin in Chinese mitten-handed crab (Eriocheir sinensis)

Tang, Jun; Yang, Xianle; Zheng, Zhong; Yu, Wenjuan; Hu, Kun; Yu, Hao

doi:10.1016/j.aquaculture.2006.05.036

Cited by 39 publications

(42 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are no reports about the temporal changes of Trx1 transcript in response to bacterial challenge in crustaceans. In the present study, the expression level of EsTrx1 was measured after crabs were challenged with L. anguillarum, an important bacterial pathogen affecting aquaculture [47] and E. sinensis [48]. The expression level of EsTrx1 mRNA was up-regulated and reached the maximum level at 6 h post-stimulation.…”

Section: Discussionmentioning

confidence: 99%

A thioredoxin with antioxidant activity identified from Eriocheir sinensis

Zhao

Wang

et al. 2009

Fish & Shellfish Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

A thioredoxin with antioxidant activity identified from Eriocheir sinensis

Zhao

Wang

et al. 2009

Fish & Shellfish Immunology

View full text Add to dashboard Cite

“…ENR is oxidatively de-ethylated into CIP by cytochrome P450 enzymes in many animal species, including fish and crustaceans (Vaccaro et al, 2003;Tang et al, 2006). In this study, the metabolization of ENR into CIP was recorded already at the first day of treatment with feed containing ENR.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Elimination of enrofloxacin in striped catfish (Pangasianodon hypophthalmus) following on-farm treatment

et al. 2015

View full text Add to dashboard Cite

“…When a desired steady-state hemolymph concentration of 2 µg OTC mL −1 is achieved, the dose of intramuscular administration is calculated to be 23.67 mg OTC kg −1 . The bioavailability of drug after oral administration is 30% of that after intramuscular administration (Yang et al, 2003). Therefore, the dose of oral administration is suggested to be 80 mg OTC kg −1 for shrimp, similar to the level used in practice.…”

Section: Discussionmentioning

confidence: 96%

“…In American lobster (Homarus americanus), the elimination half-life of 2-naphthol was significantly longer in males (63.9 h) than in females (30.6 h) (Li and James, 1997). Likewise, in crab (Eriocheir Sinensis), the elimination half-life of ciprofloxacinum in males (40.34 h) is approximately 2-fold that in females (22.07 h) (Yang et al, 2003). In the present study, the elimination half-life of OTC in F. chinensis was slightly longer in females (19.58 h) than in males (16.11 h) (Table 1), showing no significant effect of gender on the elimination of OTC in shrimps.…”

Section: Discussionmentioning

confidence: 99%

Lack of gender effect on the pharmacokinetics of oxytetracycline in Fenneropenaeus chinensis after intramuscular administration

Sun

Chang

et al. 2015

J. Ocean Univ. China

View full text Add to dashboard Cite

Fenneropenaeus chinensis, an economically important shrimp species, currently suffers from epizootic diseases due to high density stocking and bacterial infections. Oxytetracycline (OTC) has been widely used to treat various systemic bacterial infections in shrimp farming. In the present study, the effect of gender on pharmacokinetics of OTC in F. chinensis was investigated. The OTC concentrations in hemolymph of shrimp after single intramuscular administration (75 mg OTC per kg body weight) were analyzed by high performance liquid chromatography and best described with a two-compartment open model which is characterized by a short elimination half-life, low clearance, and a relatively large apparent volume of distribution. The pharmacokinetic equations were C t = 58.54e −0.38t + 11.67e −0.04t for females; and C t = 27.94e −0.28t + 14.87e −0.04t for males. The distribution and elimination half-lives of OTC were 1.82 and 19.58 h, respectively, in females and 2.50 and 16.11 h, respectively, in males at 22℃. The areas under the drug concentration curve were 480 mg L −1 h −1 in females and 430 mg L −1 h −1 in males. The total body clearance of the drug was 157.11 mL kg −1 h −1 in females and 172.47 mL kg −1 h −1 in males. The apparent volume distribution was 4.44 in females and 4.01 L kg −1 in males. There was no significant difference in pharmacokinetic parameters between female and male shrimps, indicating that there is no need to consider the gender effect in clinical use of OTC in F. chinensis farming.

show abstract

Pharmacokinetics and the active metabolite of enrofloxacin in Chinese mitten-handed crab (Eriocheir sinensis)

Cited by 39 publications

References 17 publications

A thioredoxin with antioxidant activity identified from Eriocheir sinensis

A thioredoxin with antioxidant activity identified from Eriocheir sinensis

Elimination of enrofloxacin in striped catfish (Pangasianodon hypophthalmus) following on-farm treatment

Lack of gender effect on the pharmacokinetics of oxytetracycline in Fenneropenaeus chinensis after intramuscular administration

Contact Info

Product

Resources

About