Pharmacokinetics and safety of the sesame lignans, sesamin and episesamin, in healthy subjects

Tomimori, Namino; Tanaka, Yasuhiro; Kitagawa, Yuichi; Fujii, Wataru; Sakakibara, Yutaka; Shibata, Hiroshi

doi:10.1002/bdd.1862

Cited by 39 publications

(38 citation statements)

References 32 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…e administration of sesamin alleviated blood-brain barrier disruption in mice with traumatic brain injury and reduced the size of brain infarct in ischemic mice [23]. Additionally, the pharmacokinetics of sesamin in humans showed that sesamin was detected in blood at 5 h after ingestion and cleared from the body within 24 h. ese data confirmed the safety of sesamin use in humans [24]. From these reports, sesamin has become an interesting phytochemical compound for neurodegenerative disease treatment.…”

Section: Discussionmentioning

confidence: 74%

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Udomruk

Kaewmool

Phitak

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

e promotion of neurogenesis can be a promising strategy to improve and restore neuronal function in neurodegenerative diseases. Nerve growth factor (NGF) plays a key role in neurite outgrowth and synaptic formation during brain repair stage. Nowadays, there are several studies on the developing methods to enhance the endogenous NGF activity for treatment and restore the neuronal function. In this study, the potentiating effect of sesamin, a major lignan in sesame seeds (Sesamum indicum) and oil, on NGF-induced neurogenesis and its involved mechanisms were firstly reported. Sesamin effectively enhanced the PC12 neuronlike cell differentiation and neurite length under insufficient conditions of NGF. e neuronal markers including synaptophysin and growth-associated protein-43 along with the synaptic connections were significantly increased in combination treatment between sesamin and NGF. Moreover, sesamin also increased the level of phospho-ERK1/2 and SIRT1 protein, an important regulatory protein of the neurogenesis process. e neurogenesis was blocked by the specific SIRT1 inhibitor, JGB1741, suggesting that the neuritogenic effect of sesamin was associated with SIRT1 protein modulation. Taken together, the potentiating effect of sesamin on NGF-induced neurogenesis in this finding could be used for alternative treatment in neurodegenerative diseases, including Alzheimer's disease.

show abstract

Section: Discussionmentioning

confidence: 74%

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Udomruk

Kaewmool

Phitak

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Sesamin and SC‐1 were measured by ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) as previously described (Tomimori et al . ).…”

Section: Methodsmentioning

confidence: 97%

“…Plasma samples were extracted after hydrolysis with β-glucuronidase/arylsulfatase. Sesamin and SC-1 were measured by ultraperformance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) as previously described (Tomimori et al 2013).…”

Section: Plasma Concentrations Of Sesamin and Sc-1mentioning

confidence: 99%

Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high‐fat diet‐induced diabetes

Takada

Kinugawa

Matsushima

et al. 2015

Experimental Physiology

Self Cite

View full text Add to dashboard Cite

New Findings What is the central question of this study? Our aim was to examine whether sesamin can prevent a decline in exercise capacity in high‐fat diet‐induced diabetic mice. Our hypothesis was that maintenance of mitochondrial function and attenuation of oxidative stress in the skeletal muscle would contribute to this result. What is the main finding and its importance? The new findings are that sesamin prevents the diabetes‐induced decrease in exercise capacity and impairment of mitochondrial function through the inhibition of NAD(P)H oxidase‐dependent oxidative stress in the skeletal muscle. Sesamin may be useful as a novel agent for the treatment of diabetes mellitus. AbstractWe previously reported that exercise capacity and skeletal muscle mitochondrial function in diabetic mice were impaired, in association with the activation of NAD(P)H oxidase. It has been reported that sesamin inhibits NAD(P)H oxidase‐induced superoxide production. Therefore, we examined whether the antioxidant sesamin could prevent a decline in exercise capacity in mice with high‐fat diet (HFD)‐induced diabetes. C57BL/6J mice were fed a normal diet (ND) or HFD, then treated or not with sesamin (0.2%) to yield the following four groups: ND, ND+Sesamin, HFD and HFD+Sesamin (n = 10 each). After 8 weeks, body weight, fat weight, blood glucose, insulin, triglyceride, total cholesterol and fatty acid were significantly increased in HFD compared with ND mice. Sesamin prevented the increases in blood insulin and lipid levels in HFD‐fed mice, but did not affect the plasma glucose. Exercise capacity determined by treadmill tests was significantly reduced in HFD mice, but almost completely recovered in HFD+Sesamin mice. Citrate synthase activity was significantly decreased in the skeletal muscle of HFD mice, and these decreases were also inhibited by sesamin. Superoxide anion and NAD(P)H oxidase activity were significantly increased in HFD mice compared with the ND mice and were ameliorated by sesamin. Sesamin prevented the decline in exercise capacity in HFD‐induced diabetic mice via maintenance of mitochondrial function, fat oxidation and attenuation of oxidative stress in the skeletal muscle. Our data suggest that sesamin may be useful as a novel agent for the treatment of diabetes mellitus.

show abstract

“…The conversion of sesamin into catechol derivatives and converted further into glucuronides or sulfates in the liver [70][71][72][73] has been reported to have anti-inflammatory effect on macrophage cell line (J774.1 cells). The said sesamin metabolites have been reported to have strong inhibitory effects on the LPS-induced NO production [74].…”

Section: Liver Diseasementioning

confidence: 99%

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Aquino

Barbaza

et al. 2019

Molecules

View full text Add to dashboard Cite

The use of foodstuff as natural medicines has already been established through studies demonstrating the pharmacological activities that they exhibit. Knowing the nutritional and pharmacological significance of foods enables the understanding of their role against several diseases. Among the foods that can potentially be considered as medicine, is sesame or Sesamum indicum L., which is part of the Pedaliaceae family and is composed of its lignans such as sesamin, sesamol, sesaminol and sesamolin. Its lignans have been widely studied and are known to possess antiaging, anticancer, antidiabetes, anti-inflammatory and antioxidant properties. Modern chronic diseases, which can transform into clinical diseases, are potential targets of these lignans. The prime example of chronic diseases is rheumatic inflammatory diseases, which affect the support structures and the organs of the body and can also develop into malignancies. In line with this, studies emphasizing the anti-inflammatory and anticancer activities of sesame have been discussed in this review.

show abstract

Pharmacokinetics and safety of the sesame lignans, sesamin and episesamin, in healthy subjects

Cited by 39 publications

References 32 publications

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation

Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high‐fat diet‐induced diabetes

Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.—A Review

Contact Info

Product

Resources

About