Abstract:AimsTo investigate the pharmacokinetics and safety of prolonged paracetamol use (>72 h) for neonatal pain.MethodsNeonates were included if they received paracetamol orally or intravenously for pain treatment. A total of 126 samples were collected. Alanine aminotransferase and bilirubin were measured as surrogate liver safety markers. Paracetamol and metabolites were measured in plasma. Pharmacokinetic parameters for the parent compound were estimated with a nonlinear mixed‐effects model.ResultsForty‐eight n… Show more
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