Pharmacokinetics and residues in milk of oxytetra‐cyclines administered parenterally to dairy goats

Rule, Roberto; Moreno, Laura; Serrano, João; Román, A; Moyano, Rosario; García, José Alejos

doi:10.1111/j.1751-0813.2001.tb13023.x

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…There are no accessible data on 119 the bioavailability of OTC from the GIT of broiler chickens, although there are reports on 120 similar investigations in other animals(Dyer, 1989; Nielsen and Gyrd-Hansen, 1996) 121 suggesting that the absorption of OTC from the GIT is limited and does not exceed 50%, in 122 partial agreement with our results. 123124The most recent research has demonstrated that OTC given parenterally is very well 125 absorbed, and this has been verified in other experiments(Rule et al, 2001). Moreover, our 126 results indicate that OTC given SC and IM is absorbed to a similar extent.…”

supporting

confidence: 84%

Pharmacokinetics of oxytetracycline in broiler chickens following different routes of administration

Ziółkowski

Grabowski

Jasiecka

et al. 2016

The Veterinary Journal

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supporting

confidence: 84%

Pharmacokinetics of oxytetracycline in broiler chickens following different routes of administration

Ziółkowski

Grabowski

Jasiecka

et al. 2016

The Veterinary Journal

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“…The existence of measurable OTC residues in milk was detected two days after i/m administration. A parallel finding was reported by RULE et al (2001) in healthy Murciano-Granadina goats.…”

Section: Resultssupporting

confidence: 86%

The influence of flunixin on the elimination and milk residual patterns of oxytetracycline in dairy goats

Atef¹,

EL-Gendi²,

Afifi³

et al. 2019

Vet. arhiv

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This research assessed the impact of flunixin meglumine (FM) co-administration on the elimination and milk residual properties of oxytetracycline (OTC) in dairy goats. OTC was administered via single intravenous (i/v) and intramuscular (i/m) injections at a dose of 10 mg/kg body mass (b.m.). Serum, urine, milk and ruminal juice were analysed using high-performance liquid chromatography (HPLC). The OTC serum concentrations were higher than the MIC for 12 hours against most susceptible pathogens in both groups. The half-lives of the distribution (T 1/2α) and elimination (T 1/2β) of OTC were 0.24 and 5.79 hours, respectively. The total body clearance was significantly increased in the FM coadministered groups. Following i/m injection, the absorption half-life (T 1/2ab) with the maximum absorption time (T max) revealed a rapid absorption rate. Furthermore, the systemic bioavailability (F%) after i/m was 107.2%, indicating complete absorption from the muscular tissues. The bounded fraction of OTC with serum proteins was 18.73%. FM significantly decreases OTC concentration in milk and ruminal juice. OTC is eliminated primarily through the kidneys and to a lesser extent via milk and ruminal juice in dairy goats. Milk obtained from OTC treated goats may not be safe for human consumption two days post administration. Concomitantly, the use of FM with OTC may necessitate the surveillance and optimization of OTC dosage.

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“…Indeed, the average AUC last value of the 20 mg/kg treatment group was 662.17 ± 145.97 h·μg/mL, while a value of 800.29 ± 70.08 h·μg/mL was found in the 30 mg/kg treatment group. The t max value obtained in this study was quite longer than those reported in calves (8.0 h; Kumar & Malik, ), pigs (1.7–2.7 h; el Korchi et al ., ), and goats (2–4 h; Rule et al ., ) undergoing i.m. OTC‐LA treatment.…”

Section: Mean ± Sd Values Of the Pharmacokinetic Parameters Of A Longmentioning

confidence: 99%

Disposition of a long‐acting oxytetracycline formulation in Thai swamp buffaloes (Bubalus bubalis)

Poapolathep

Wongpanit

Tanhan

et al. 2016

Vet Pharm & Therapeutics

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The present study aimed to characterize the pharmacokinetic profile of oxytetracycline long-acting formulation (OTC-LA) in Thai swamp buffaloes, Bubalus bubalis, following single intramuscular administration at two dosages of 20 and 30 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 504 h. The plasma concentrations of OTC were measured by high-performance liquid chromatography (HPLC). The concentrations of OTC in the plasma were determined up to 264 h and 432 h after i.m. administration at doses of 20 and 30 mg/kg b.w., respectively. The C values of OTC were 12.11 ± 1.87 μg/mL and 12.27 ± 1.92 μg/mL at doses of 20 and 30 mg/kg, respectively. The AUC values increased in a dose-dependent fashion. The half-life values were 52.00 ± 14.26 h and 66.80 ± 10.91 h at doses of 20 and 30 mg/kg b.w, respectively. Based on the pharmacokinetic data and PK-PD index (T > MIC), i.m. administration of OTC at a dose of 30 mg/kg b.w once per week might be appropriate for the treatment of susceptible bacterial infection in Thai swamp buffaloes.

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Pharmacokinetics and residues in milk of oxytetra‐cyclines administered parenterally to dairy goats

Cited by 10 publications

References 17 publications

Pharmacokinetics of oxytetracycline in broiler chickens following different routes of administration

Pharmacokinetics of oxytetracycline in broiler chickens following different routes of administration

The influence of flunixin on the elimination and milk residual patterns of oxytetracycline in dairy goats

Disposition of a long‐acting oxytetracycline formulation in Thai swamp buffaloes (Bubalus bubalis)

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