Pharmacokinetics and pharmacodynamics of serum platinum of gynecologic cancer patients treated with nedaplatin

Matsumoto, Yoshinari; Ishiko, Osamu; Nakagawa, Eiichiro; Sumi, Toshiyuki; Hyun, Yooji; Ando, Yoshiya; Ogita, Sachio

doi:10.3892/or.8.6.1269

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“…However, according to a study, in these patients, the serum level of nedaplatin remained high for a long duration, and side effects, including renal toxicity, should be considered. 21) The grade of nephrotoxicity related to nedaplatin and cisplatin was dose dependent, and was similar at the doses at which kidney accumulation was similar. A study has reported that cisplatin-related nephrotoxicity is dose-dependent 10,11) ; our results supported this finding.…”

Section: Discussionmentioning

confidence: 89%

Relationship between Cisplatin or Nedaplatin-Induced Nephrotoxicity and Renal Accumulation

Kawai

Taniuchi

Okahara

et al. 2005

Biological & Pharmaceutical Bulletin

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Nedaplatin is known to exhibit antitumor activity similar to that of cisplatin. However, concerning side effects, nedaplatin causes renal toxicity less frequently than cisplatin. In this study, we compared the incidence of renal toxicity between cisplatin and nedaplatin by investigating the difference in kidney tissue accumulation. Kidney tissue accumulation of cisplatin administered at 3.75 mg/kg was similar to that of nedaplatin administered at 24 mg/kg. At these doses, the plasma creatinine level and urinary excretion of glucose and N-acetyl-b b-D-glucosaminidase (NAG) similarly increased. There was a correlation between kidney accumulation of cisplatin and nedaplatin and the increases in plasma creatinine level and urinary excretion of NAG. Therefore, our results suggest that nedaplatin less frequently causes renal toxicity in comparison to cisplatin due to lower kidney accumulation.

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Section: Discussionmentioning

confidence: 89%