Pharmacokinetics and Pharmacodynamics of Org 9426 in Elderly Surgical Patients

Matteo, Richard S.; Ornstein, Eugene; Schwartz, Arthur E.; Stone, J.; Ostapkovich, Noeleen; Spencer, H K; Dee, Cathryn M.

doi:10.1097/00000542-199109001-01064

Cited by 5 publications

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“…In addition, the number of motor units in a muscle is decreased in the elderly, compared to younger adults and muscular atrophy is present. A decrease in cardiac output and increased circulation time lead to a delay in the onset of drugs, including muscle relaxants 85 . Dehydration and change in body composition result in an apparently increased sensitivity to relaxants 86 .…”

Section: The Use Of Relaxants At the Extremes Of Agementioning

confidence: 99%

Skeletal Muscle Relaxants: Pharmacodynamics and Pharmacokinetics in Different Patient Groups

Booij

Vree

2000

Int J Clinical Practice

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SUMMARYMuscle relaxants can be safely administered during anaesthesia, providing the basic pharmacodynamic and pharmacokinetic characteristics of the compounds together with the physiological status of the patient are known. In this review the pharmacodynamics and pharmacokinetics of the neuromuscular blocking agents are discussed and related to the physical health or disease state of groups of patients.

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Section: The Use Of Relaxants At the Extremes Of Agementioning

confidence: 99%

Skeletal Muscle Relaxants: Pharmacodynamics and Pharmacokinetics in Different Patient Groups

Booij

Vree

2000

Int J Clinical Practice

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Pharmacodynamic behaviour of rocuronium in the elderly

et al. 1993

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This study compared the potency and time course of action of rocuronium (ORG 9426) in elderly and young patients during nitrous oxide-opioid anaesthesia. One hundred ASA physical status l-H patients (60, aged 65-80 yr, and 40, aged 20-45 yr) were studied by measuring the force of contraction of the adductor pollicis in response to train-of-four stimulation of the ulnar nerve. After induction of anaesthesia with thiopentone and maintenance with N20/ O 2 and fentanyl, rocuronium 120, 160, 200, or 240 #g" kg -t (3,7 • 1,1(SD) vs 3,1 + 0,9 P < 0,05). La p6riode de recouvrement de T t h 25% se prolonge dans le groupe ~gd (11,8 • 8,1 vs 8,0 • 6,5 rain, P < 0,05) de m~me que l'index de rdcup6ration (5,5 + 6,2 vs H,2 • 4,9 min, P < 0,05

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Pharmacokinetics and Pharmacodynamics of Steroidal Muscle Relaxants

Ducharme

Donati

1993

Anesthesiology Clinics of North America

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Pharmacokinetics and Pharmacodynamics of Org 9426 in Elderly Surgical Patients

Cited by 5 publications

References 0 publications

Skeletal Muscle Relaxants: Pharmacodynamics and Pharmacokinetics in Different Patient Groups

Skeletal Muscle Relaxants: Pharmacodynamics and Pharmacokinetics in Different Patient Groups

Pharmacodynamic behaviour of rocuronium in the elderly

Pharmacokinetics and Pharmacodynamics of Steroidal Muscle Relaxants

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