Pharmacokinetics and pharmacodynamics of cimetidine and metabolites in critically ill children

Lloyd, Charles W.; Martin, William J.; Taylor, Bruce D.; Hauser, Allen R.

doi:10.1016/s0022-3476(85)80155-4

Cited by 21 publications

(12 citation statements)

References 20 publications

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“…1). However, we excluded 13 studies because they were nonrandomized or noncontrolled or focused on pharmacokinetics of drugs (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). One study in Hungarian is pending for evaluation (25).…”

Section: Description Of Studiesmentioning

confidence: 99%

Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: A systematic review

Revéiz

Guerrero‐Lozano

Camacho

et al. 2010

Pediatric Critical Care Medicine

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Section: Description Of Studiesmentioning

confidence: 99%

Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: A systematic review

Revéiz

Guerrero‐Lozano

Camacho

et al. 2010

Pediatric Critical Care Medicine

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“…H2-Receptor antagonists are used in in fants and children as therapeutic adjuncts in the treatment of gastric or duodenal ulcers, gastrointestinal hemorrhage and prophylaxis of stress ulceration [1][2][3][4]. In the intensive care setting, parenteral ^-blocking agents may be indicated when serious risk of muco sal ulceration is present and oral treatment is not possible, as in persistent vomiting or ileus [4,5].…”

mentioning

confidence: 99%

Pharmacokinetics of Ranitidine in Critically Ill Infants

et al. 1989

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The pharmacokinetic parameters of ranitidine were studied following administration of a single intravenous dose in 9 critically ill infants. Ranitidine disposition was best described by a biphasic elimination curve. For 8 patients, the mean values for T 1/2, apparent volume of distribution, and total body clearance were 2.09 h, 1.61 l/kg, and 13.93 ml/min/kg, respectively. Based on simulated steady-state concentration profiles, a dose of 0.7 mg/kg administered intravenously every 6 h should maintain serum levels above 40 ng/ml for 4.7 h of the dosing interval with a wide degree of variability.

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“…V max for thyroid iodide uptake was adjusted for all clearance rates to fit literature data shown in Clewell et al (5) f High value was estimated as published in Clewell et al (5) by using iodide and perchlorate urinary clearance constants equal to the average adult and the constants were scaled by BW 0.75 . Medium used the same constants but scaled by BW 1 ; this scaling described the average renal excretion of cimetidine (36) better. The low clearance was estimated by scaling by BW 1 and multiplying by the ratio (0.76) of the lower 95% confidence bound to the mean for the Lloyd et al (36) data.…”

Section: Evaluation Of Specialized Model Analysesmentioning

confidence: 99%

“…Medium used the same constants but scaled by BW 1 ; this scaling described the average renal excretion of cimetidine (36) better. The low clearance was estimated by scaling by BW 1 and multiplying by the ratio (0.76) of the lower 95% confidence bound to the mean for the Lloyd et al (36) data. concentrations, 15, 20, and 24.5 µg/L with and without the contribution of food (Table IV).…”

Section: Evaluation Of Specialized Model Analysesmentioning

confidence: 99%

The Use of PBPK Models to Inform Human Health Risk Assessment: Case Study on Perchlorate and Radioiodide Human Lifestage Models

et al. 2013

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Physiologically-based pharmacokinetic (PBPK) models are often submitted to or selected by agencies, such as the U.S. Environmental Protection Agency (U.S. EPA) and Agency for Toxic Substances and Disease Registry, for consideration for application in human health risk assessment (HHRA). Recently, U.S. EPA evaluated the human PBPK models for perchlorate and radioiodide for their ability to estimate the relative sensitivity of perchlorate inhibition on thyroidal radioiodide uptake for various population groups and lifestages. The most well-defined mode of action of the environmental contaminant, perchlorate, is competitive inhibition of thyroidal iodide uptake by the sodium-iodide symporter (NIS). In this analysis, a six-step framework for PBPK model evaluation was followed, and with a few modifications, the models were determined to be suitable for use in HHRA to evaluate relative sensitivity among human lifestages. Relative sensitivity to perchlorate was determined by comparing the PBPK model predicted percent inhibition of thyroidal radioactive iodide uptake (RAIU) by perchlorate for different lifestages. A limited sensitivity analysis indicated that model parameters describing urinary excretion of perchlorate and iodide were particularly important in prediction of RAIU inhibition; therefore, a range of biologically plausible values available in the peer-reviewed literature was evaluated. Using the updated PBPK models, the greatest sensitivity to RAIU inhibition was predicted to be the near-term fetus (gestation week 40) compared to the average adult and other lifestages; however, when exposure factors were taken into account, newborns were found to be populations that need further evaluation and consideration in a risk assessment for perchlorate.

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Pharmacokinetics and pharmacodynamics of cimetidine and metabolites in critically ill children

Cited by 21 publications

References 20 publications

Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: A systematic review

Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: A systematic review

Pharmacokinetics of Ranitidine in Critically Ill Infants

The Use of PBPK Models to Inform Human Health Risk Assessment: Case Study on Perchlorate and Radioiodide Human Lifestage Models

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