Pharmacokinetics and Pharmacodynamics of Chaga Birch Mushroom Components (Inonotus Obliquus)

Abstract

The study presents an analysis of the available scientific literature and outcomes of clinical trials on biologically active components of the birch Chaga mushroom Inonotus obliquus (I. obliquus). Our experimental and clinical studies were aimed at testing a novel plant-based substance for patients with cancer or tumors of various locations. The paper investigates pathogenetic mechanisms and effectiveness of chaga mushroom extracts depending on the topography of the tumor, the stage of the disease and the age of patients, as well as the questions of pharmacokinetics and pharmacodynamics of the components of I. obliquus. As a result of the analysis of the obtained data, the pathogenetically justified clinical application of extracts of the birch chaga mushroom I. obliquus in patients with oncological pathology was conceptually presented. The study allowed us to reveal possible mechanisms of pathogenetic effects of the birch chaga mushroom (Inonotus obliquus) extracts obtained by different extraction methods. Analysis of the available data enabled us to deepen our understanding of the effectiveness and mechanisms of the effect of the I. obliquus extracts on tumors of various localization. Finally we present recommendations on predicting the possibility of using the I. obliquus to improve outcomes in patients with cancer of various etiology and locations.