Pharmacokinetics and metabolism of N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-l-phenylalanine 1-methyl ester, monohydrate (advantame) in the rat, dog, and man

Ubukata, Kazuyuki; Nakayama, Akira; Mihara, Ryuichi

doi:10.1016/j.fct.2011.06.042

Cited by 11 publications

(7 citation statements)

References 4 publications

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“…A relatively new and increasingly used LCS, a mixture of steviol glycosides isolated from the leaf of Stevia rebaudiana , undergoes bacterial hydrolysis in the gut prior to absorption and subsequent excretion in urine as steviol glucuronide [ 117 – 119 ]. Advantame is deesterified to advantame acid and a small proportion is absorbed (~ 6%) and excreted via the urine [ 120 ]. The excretion products of acesulfame-K, saccharin, sucralose, cyclamates, steviol glycosides, and advantame are highly specific to exposures to the parent compound per se as they are not produced endogenously.…”

Section: Resultsmentioning

confidence: 99%

Biomarkers of intake for coffee, tea, and sweetened beverages

et al. 2018

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Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases. A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention studies or as biomarkers of intake to improve measurements of beverage consumption in cohort studies and reveal new associations with disease outcomes that may have been overlooked when using dietary questionnaires. Here, biomarkers of intake of some major non-alcoholic beverages—coffee, tea, sugar-sweetened beverages, and low-calorie-sweetened beverages—are reviewed. Results from dietary intervention studies and observational studies are reviewed and analyzed, and respective strengths and weaknesses of the various identified biomarkers discussed. A variety of compounds derived from phenolic acids, alkaloids, and terpenes were shown to be associated with coffee intake and trigonelline and cyclo(isoleucylprolyl) showed a particularly high specificity for coffee intake. Epigallocatechin and 4′-O-methylepigallocatechin appear to be the most sensitive and specific biomarkers for green or black tea, while 4-O-methylgallic acid may be used to assess black tea consumption. Intake of sugar-sweetened beverages has been assessed through the measurement of carbon-13 enrichment of whole blood or of blood alanine in North America where sugar from sugarcane or corn is used as a main ingredient. The most useful biomarkers for low-calorie-sweetened beverages are the low-calorie sweeteners themselves. Further studies are needed to validate these biomarkers in larger and independent populations and to further evaluate their specificity, reproducibility over time, and fields of application.Electronic supplementary materialThe online version of this article (10.1186/s12263-018-0607-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Biomarkers of intake for coffee, tea, and sweetened beverages

et al. 2018

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“…Most have been approved for use as a food additive and, as such, have undergone a premarket approval process in accordance with stipulations made by Additional information regarding NNSs can be found in previously published review articles. 10,21,22,38,43,[51][52][53][54][55][56][57][58][59][60][61]…”

Section: Sweeteners and Nnssmentioning

confidence: 99%

The Use of Nonnutritive Sweeteners in Children

2019

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The prevalence of nonnutritive sweeteners (NNSs) in the food supply has increased over time. Not only are more children and adolescents consuming NNSs, but they are also consuming a larger quantity of NNSs in the absence of strong scientific evidence to refute or support the safety of these agents. This policy statement from the American Academy of Pediatrics is intended to provide the pediatric provider with a review of (1) previous steps taken for approved use of NNSs, (2) existing data regarding the safety of NNS use in the general pediatric population, (3) what is known regarding the potential benefits and/or adverse effects of NNS use in children and adolescents, (4) identified gaps in existing knowledge and potential areas of future research, and (5) suggested talking points that pediatricians may use when discussing NNS use with families This document is copyrighted and is property of the American Academy of Pediatrics and its Board of Directors. All authors have filed conflict of interest statements with the American Academy of Pediatrics. Any conflicts have been resolved through a process approved by the Board of Directors. The American Academy of Pediatrics has neither solicited nor accepted any commercial involvement in the development of the content of this publication. The guidance in this statement does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate. All policy statements from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.

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“…Sections were exposed by contact with an Imaging-Plate BAS-III2040 (Fuji Photo Film, Tokyo, Japan) in a shield box for 16 h. After exposure, the Imaging-Plate was analyzed with a Bio-Imaging Analyzer BAS-2000 (Fuji Photo Film, Tokyo, Japan) to obtain macro-autoradioluminograms and measure radioactivities in the tissues. The concentration of the radioactivity in the tissue was quantified by the absolute calibration method [14,15,16,17]. The calibration curve through the origin (Y = aX) was prepared based on the mean value of the intensity of luminescence (PSL-BG/mm 2 ) of the blood simultaneously collected when stomach was removed and blood concentration of acotiamide determined by a liquid scintillation analyzer LSC-6100 (Aloka, Tokyo, Japan).…”

Section: Macro-autoradiography Of Rat Stomachmentioning

confidence: 99%