Pharmacokinetics and electrophysiological effects of sotalol hydrochloride in horses

Broux, Barbara; Clercq, Dominique De; Decloedt, Annelies; Vera, Lisse; Devreese, Mathias; Gehring, Ronette; Croubels, Siska; Loon, Gunther van

doi:10.1111/evj.12765

Cited by 18 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, the sotalol plasma concentrations were probably below the therapeutic range described in human medicine. Plasma concentrations were not measured in our study, but the steady state plasma concentration was 287 ng/mL in horses receiving 2 mg/kg body weight sotalol PO twice daily for 9 days, while fed hay ad libitum during the day . This is lower than the therapeutic plasma concentrations of 1000–3000 ng/mL described in human medicine .…”

Section: Discussioncontrasting

confidence: 65%

“…Plasma concentrations were not measured in our study, but the steady state plasma concentration was 287 ng/mL in horses receiving 2 mg/kg body weight sotalol PO twice daily for 9 days, while fed hay ad libitum during the day. 11 This is lower than the therapeutic plasma concentrations of 1000-3000 ng/mL described in human medicine. 24 However, the significant QT prolongation indicates class III activity despite the low plasma concentrations.…”

Section: Discussionmentioning

confidence: 82%

“…Third, the β‐blocking activity of sotalol might result in a negative inotropic effect and might affect blood pressure during exercise. However, the negative inotropic effect is counteracted by the class III activity, and no alterations of blood pressure have been described at rest in horses receiving sotalol . Finally, sotalol cannot be used in horses during competition, because it is listed in the Fédération Equestre Internationale prohibited substances database as a controlled medication.…”

Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, sotalol is the most commonly used long‐term treatment for hemodynamically important ventricular arrhythmias in dogs and cats . In healthy horses, sotalol results in prolongation of the QT interval . However, the use of sotalol has not been described in horses with cardiac arrhythmias, except in 2 recent reports describing single cases …”

Section: Introductionmentioning

confidence: 99%

“…10 In healthy horses, sotalol results in prolongation of the QT interval. 7,11 However, the use of sotalol has not been described in horses with cardiac arrhythmias, except in 2 recent reports describing single cases. 12,13 Our objectives were to assess the effect of sotalol on HR, QT interval, atrial fibrillatory rate, and success of cardioversion in horses with AF.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Effect of sotalol on heart rate, QT interval, and atrial fibrillation cycle length in horses with atrial fibrillation

Decloedt

Broux

Clercq

et al. 2018

Veterinary Internal Medicne

Self Cite

View full text Add to dashboard Cite

BackgroundBased on its pharmacokinetic profile and electrophysiological effects in healthy horses, sotalol potentially could be used as a long‐term PO antiarrhythmic drug in horses.ObjectivesTo evaluate the effect of sotalol on heart rate (HR), QT interval, atrial fibrillatory rate, and success of cardioversion in horses with naturally occurring chronic atrial fibrillation (AF).AnimalsTwenty‐eight horses referred for transvenous electrical cardioversion of AF were treated with 2 mg/kg sotalol PO q12h for 3 days before cardioversion, and 13 horses underwent the same protocol without sotalol administration.MethodsRetrospective study. Before and after sotalol or no treatment, the HR was measured at rest and during an exercise test. The QT interval and atrial fibrillation cycle length (AFCL) were measured at rest using tissue Doppler velocity imaging.ResultsIn the control group, no significant differences were found between the 2 examinations. In the sotalol group, the HR at rest and during exercise was significantly lower after sotalol treatment, whereas the QT interval and AFCL measured by tissue Doppler increased significantly. Cardioversion to sinus rhythm was achieved in 25/28 horses in the sotalol group and all horses in the control group, but the median number of shocks and energy at cardioversion were significantly lower in the sotalol group.Conclusions and Clinical ImportanceIn horses with AF, sotalol administration results in class III antiarrhythmic effects and β‐blocking activity, with moderate HR reduction during exercise.

show abstract

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations