Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease

Pereira, Stephen P.; Rowbotham, David; Fitt, S; Shearer, Martin J.; Wendon, Julia; Williams, Roger

doi:10.1016/j.jhep.2004.11.030

Cited by 75 publications

(36 citation statements)

References 26 publications

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“…intake were also well comparable with previously published data [35]. Interestingly, phylloquinone serum half-lives in patients with severe acute liver disease were approximately two-fold longer than those found in subjects with normal hepatic function [38]. Furthermore, terminal half-lives of vitamin K1 in newborns were also considerably longer compared to adults [37].…”

Section: First Application Of the Hplc Methods In A Pharmacological Stsupporting

confidence: 90%

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

Marinova¹,

Lütjohann

Westhofen³

et al. 2011

TOCCHEMJ

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Dietary phylloquinone (vitamin K1) is considered to be a major determinant of human vitamin K status. For this reason, measurements of plasma vitamin K concentrations provide a useful tool of vitamin K status in man. There is a growing interest in the role, biochemical function, and metabolism of vitamin K in vivo.A modified reversed phase-HPLC method with fluorescence detection after post-column zinc reduction in serum samples was validated for vitamin K analysis. Two human volunteers were investigated after p.o. and i.v. administration of 2 mg Konakion ® MM. Blood samples were collected periodically after administration and subjected to pharmacokinetic evaluation.High sensitivity, analytical recoveries, accuracy and calibration curves linearities could be reached. Our results showed an overall coefficient of variation of less than 10% for the intra-and interday reproducibility, while the recovery ranged from 91% to 114 %. The limit of detection and quantification were 0.015 ng mL -1 and 0.15 ng mL -1 , respectively. Long-term stability was verified over a period of six months. The accuracy was proven by good results from external quality assurance.The observed pharmacokinetic differences indicate significant intra-and inter-individual variance of vitamin K fate in the human body.This highly accurate, robust and reliable method is appropriate for the evaluation of vitamin K status in human serum. The ability to determine vitamin K has the potential to improve pharmacokinetic studies.

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Section: First Application Of the Hplc Methods In A Pharmacological Stsupporting

confidence: 90%

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

Marinova¹,

Lütjohann

Westhofen³

et al. 2011

TOCCHEMJ

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“…Intravenous injection of 10 mg daily of vitamin K for 24-48 h may restore vitamin deficiency secondary to cholestasis or malabsorption [137]. However, in patients with impaired synthetic liver function, administration of vitamin K is ineffective in normalizing PT/INR values [137][138][139].…”

Section: Vitamin Kmentioning

confidence: 99%

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

Andriulli

Tripodi

Angeli

et al. 2016

Digestive and Liver Disease

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a b s t r a c tPatients with cirrhosis present with hemostatic alterations secondary to reduced availability of procoagulant and anti-coagulant factors. The net effect of these changes is a rebalanced hemostatic system. The Italian Association of the Study of the Liver (AISF) and the Italian Society of Internal Medicine (SIMI) promoted a consensus conference on the hemostatic balance in patients with cirrhosis. The consensus process started with the review of the literature by a scientific board of experts and ended with a formal consensus meeting in Rome in December 2014. The statements were graded according to quality of evidence and strength of recommendations, and approved by an independent jury. The statements presented here highlight strengths and weaknesses of current laboratory tests to assess bleeding and thrombotic risk in cirrhotic patients, the pathophysiology of hemostatic perturbations in this condition, and outline the optimal management of bleeding and thrombosis in patients with liver cirrhosis.

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“…For patients able to take PO medications, oral vitamin K is a reasonable alternative. Oral and IV administration are both effective at INR reversal (23). Oral vitamin K doses of 2.5-5 mg were found to have similar efficacy to 0.5-1 mg IV vitamin K in one study, although other studies have used doses of 10 mg oral or IV (23,24).…”

Section: Phytonadione Vitamin K (Intravenous)mentioning

confidence: 97%

Disruptions in the Supply of Medications Used in Transplantation: Implications and Management Strategies for the Transplant Clinician

Krisl

Fortier

Taber

2013

American Journal of Transplantation

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Drug shortages are a threat to patient care and public health, and the number of drugs on shortage is growing at an exponential rate. The major therapy areas affected by these shortages are oncology, anti-infective, cardiovascular and central nervous system. However, drugs utilized in the transplant patient population have not been exempt, and can have significant influence on posttransplant outcomes. The purpose of this review is to discuss the current and historical solid organ transplant-related disruptions in the supply of medications and implications on patient care and safety. Transplant centers should be armed with an implementation plan when imperative transplant-related drugs such as tacrolimus, mycophenolate, or antithymocyte globulin go on shortage. This plan should provide steps to manage the shortage, and provide effective therapeutic alternatives.

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Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease

Abstract: A minority of patients with severe acute liver dysfunction have subclinical vitamin K deficiency at the time of presentation, which is corrected by a single dose of i.v. K1. The intestinal absorption of mixed-micellar K1 is unreliable in adults with severe acute liver dysfunction.

Cited by 75 publications

References 26 publications

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

A Validated HPLC Method for the Determination of Vitamin K in Human Serum – First Application in a Pharmacological Study

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

Disruptions in the Supply of Medications Used in Transplantation: Implications and Management Strategies for the Transplant Clinician

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