Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity

Olsén, Lena; Bondesson, Ulf; Broström, Hans; Olsson, Ulf; Mazogi, Behnaz; Sundqvist, M; Tjälve, Hans; Ingvast-Larsson, C.

doi:10.1016/j.tvjl.2009.12.030

Cited by 28 publications

(39 citation statements)

References 32 publications

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“…In the second study conducted by Olsen et al . (), only samples collected up to 24 h postadministration of the final dose were included in the analysis. In the current study as well as the first study by Olsen et al .…”

Section: Accuracy and Precision Values For Lc‐ms/ms Analysis Of Cetirmentioning

confidence: 99%

Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses

Knych

Stanley

Arthur

et al. 2016

Vet Pharm & Therapeutics

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Cetirizine is an antihistamine used in performance horses for the treatment of hypersensitivity reactions and as such a withdrawal time is necessary prior to competition. The objective of the current study was to describe the disposition and elimination of cetirizine following oral administration in order to provide additional serum concentration data upon which appropriate regulatory recommendations can be established. Nine exercised thoroughbred horses were administered 0.4 mg/kg of cetirizine orally BID for a total of five doses. Blood samples were collected immediately prior to drug administration and at various times postadministration. Serum cetirizine concentrations were determined and selected pharmacokinetic parameters determined. The serum elimination half-life was 5.83 ± 0.841 h. Average serum cetirizine concentrations were still above the LOQ of the assay (0.05 ng/mL) at 48 h (final sample collected) postadministration of the final dose.

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Section: Accuracy and Precision Values For Lc‐ms/ms Analysis Of Cetirmentioning

confidence: 99%

Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses

Knych

Stanley

Arthur

et al. 2016

Vet Pharm & Therapeutics

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“…The clinical use (Olsén et al . ; Lassaline‐Utter et al . ) and pharmacokinetics and pharmacodynamics of cetirizine have been investigated in the horse (Olsén et al .…”

Section: Discussionmentioning

confidence: 99%

Dermatographism in a horse, responsive to cetirizine treatment

Brom‐Spierenburg

Theelen

Oldruitenborgh‐Oosterbaan

2017

Equine Veterinary Education

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Summary Dermatographism is a common condition in man that occurs when pressure is applied to the skin and mast cells are triggered to release histamine, causing local urticarial lesions. This case report concerns a 4‐year‐old Quarter Horse gelding that was presented with pressure induced urticaria. Moderate pressure on the skin induced nonpruritic urticaria‐like swelling after approximately 3–5 min, which lasted for approximately 2–3 h. Initial treatment with cyproheptadine gave an incomplete response and unacceptable sedation as a side effect. On the second generation antihistamine cetirizine (0.2 mg/kg bwt twice daily), dermatographism was no longer present and no side effects occurred. Treatment was continued for 4 months, with at least three attempts to discontinue therapy resulting in recurrence of lesions within 24 h. Lesions resolved each time within 24 h of recommencing therapy. Dermatographism did not recur after the horse was moved to another location despite discontinuation of therapy. This report describes a case of equine dermatographism responsive to cetirizine.

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“…It is important to investigate an effect of the environmental factors while estimating true genetic component influencing IBH susceptibility in horses. The environmental factors related to exposure to allergens like region of habitat of horses (exposure to allergens) (Eriksson et al, 2008;Brostrom et al, 1987), time period of collection of data (Schurink et al, 2013b), protective rugs (Olsen et al, 2011) have been observed to influence IBH prevalence. The environmental factors related to mares such as age, coat colour, wither height, body condition (amount of fat stored in the body) (Peeters et al, 2014;Schurink et al, 2013b) had significant effect on IBH prevalence.…”

Section: Insect Bite Hypersensitivity Backgroundmentioning

confidence: 99%

“…Total avoidance of exposure might not be possible, however exposure can be decreased by use of blankets on horses, overnight stabling (avoiding the time when the biting midges are active for example sunrise and sunset) (Olsen et al, 2011). Other methods include relocating horses to low-risk areas and use of insect repellents as reviewed in Schaffartzik et al (2012).…”

Section: Prevention and Treatmentmentioning

confidence: 99%

“…Environmental factors such as age, coat colour, body condition of horse; exposure of horse to allergens; preventive measures such as stabling of horses, and use of protective rugs have been suggested to influence development of IBH (Peeters et al, 2014;Schurink et al, 2013a;Olsen et al, 2011;Eriksson et al, 2008;Brostrom et al, 1987). The effect of sex on IBH development is inconclusive (Peeters et al, 2014;Eriksson et al, 2008;Brostrom et al, 1987).…”

Section: Environmentmentioning

confidence: 99%

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Genetics of equine insect bite hypersensitivity and genetic diversity in horses

Shrestha¹

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Genetic variation contributing to the phenotypic variation was utilized in this thesis to understand the genetic background of a complex trait IBH, and to understand genetic diversity and relationships between various horse populations.IBH is the most common skin allergic disorder in horses, caused by bites of midges, predominantly Culicoides species. It affects various horse breeds worldwide. With no effective treatment, IBH degrades horse health and causes economic loss. In this thesis, we used genome-wide SNPs to identify regions contributing to genetic variance of IBH susceptibility. We also investigated influence of increased number of horses and dense SNPs on identification of genomic regions associated to IBH susceptibility. Multiple genomic regions with small effects were observed in Studies I-III. Interesting genomic regions in the Icelandic horse population across the studies I and II, was observed on chromosomes 1, 7, 10, 15 and 17. The percentage of the genetic variance explained by top ten windows increased from 3.07% (Study I) to 6.56% (Study II). Novel genomic regions were identified when number of Icelandic horses was increased in Study II. Using dense SNPs on the Exmoor pony population we identified novel genomic regions, on chr 8, associated to IBH susceptibility, though with borderline significance.In Study IV, pre-conceived understanding about evolutionary history of horse populations matched obtained results from investigation of genetic relationships within Dutch warmblood populations (pairwise mean FST ≤ 0.070), and within pony-like populations (pairwise mean FST ≤ 0.078). Horse populations with similar genetic background might share similar genetic components for IBH susceptibility. The Friesian horse population had lowest diversity (mean inbreeding coefficients: fi: 30.4%, fiROH= 22.2%) in Study IV and was genetically distinct (FST ranged from 0.13 to 0.17). This might be a result of a history of several population bottlenecks and selection on a closed breeding scheme. Low diversity in immunity related genes, observed in the Friesian horse population, might have led to increased prevalence of IBH. Similarly, low susceptibility of IBH in a warmblood population, KWPN sport horse population might be due to high genetic diversity ( i f =-6.9%). High genetic diversity in KWPN sport horse population might be a result of an open breeding scheme and interbreeding with other warmblood populations.

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Pharmacokinetics and effects of cetirizine in horses with insect bite hypersensitivity

Cited by 28 publications

References 32 publications

Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses

Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses

Dermatographism in a horse, responsive to cetirizine treatment

Genetics of equine insect bite hypersensitivity and genetic diversity in horses

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