Pharmacokinetics and Bioequivalence Estimation of Two Formulations of Alfuzosin Extended‐Release Tablets

Bawab, Abdel Qader Al; Alkhalidi, Bashar A.; Albarahmieh, Esra’a; Qassim, Sami M.A.; Al-Saifi, Mohammad A D; Al‐Saifi, Bashar; Ling, Jonathan; Al‐Qerem, Walid

doi:10.1002/cpdd.860

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…The investigated method showed a satisfying sensitivity for detection of TDF and AFH in human plasma samples spiked with them. It was reported by pharmacokinetic studies that AFH showed concentrations of 2–12 ng ml −1 in plasma and 1–5 ng ml −1 in urine [57], while TDF showed plasma concentrations of 50–320 ng ml −1 and urine concentration of 25 ng ml −1 [58].…”

Section: Resultsmentioning

confidence: 99%

A synchronous spectrofluorometric technique for simultaneous detection of alfuzosin and tadalafil: applied to tablets and spiked biological samples

et al. 2022

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A facile, accurate, eco-friendly and sensitive spectrofluorometric method was evolved to assay alfuzosin hydrochloride (AFH) and tadalafil (TDF) in different matrices. Such a co-administered combination is clinically used for the treatment of lower urinary tract symptoms. Both compounds are characterized by their native fluorescence spectra upon excitation at specific wavelengths. Their characteristic fluorescence spectra were used for sensitive assay of the studied analytes in tablets and human biological samples. The assay principle is based on first-order synchronous spectrofluorometric scan using Δ λ = 60 nm in which AFH peaks were recorded at 366 nm. Meanwhile, TDF measurements were recorded at 293 nm in the same scans without overlap with AFH spectra. Recent analytical chemistry trends were implemented to lessen occupational and environmental perils, using ethanol as a diluting solvent for method optimization and application. Linearity ranges were 5.0–90.0 and 10.0–100.0 ng ml −1 for AFH and TDF, respectively in their raw materials with average % recoveries of 100.44% and 99.73% in raw materials, 100.15% and 100.20% in spiked plasma, and 97.14% and 99.99% in spiked urine. The proposed method was successfully applied to Prostetrol and Starkoprex commercial tablets with no interference with common tablet additives.

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Section: Resultsmentioning

confidence: 99%

A synchronous spectrofluorometric technique for simultaneous detection of alfuzosin and tadalafil: applied to tablets and spiked biological samples

et al. 2022

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“…The lack of analysis leaves opens the possibility that the dykes are from Tertiary basalt volcanism. In the Al Hara region, Abo Saada. (1982);reported in Al Saifi et al, (1983) assessed 2400 Joints and found that they were ENE/dip SE; NW/SW and NE; EW/gentle to subhorizontal; and NS/vertical.…”

Section: Geological Setting Of Al Taif Areamentioning

confidence: 99%

Landslide susceptibility mapping of Al Taif urban area, Saudi Arabia, using remote sensing data and microtremor measurements: integrated approach

Abdelrahman,

Al-Amri,

Al-Kahtany

et al. 2023

Front. Earth Sci.

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Many people are killed by landslides due to earthquakes or severe rain, and structures and facilities built on or near slopes sustain significant damage. Such landslides on naturally occurring slopes can be large enough to utterly destroy towns or communities. Based on remote sensing and microtremor data, the area around Al Taif has been evaluated for its susceptibility to landslides. Digital elevation model (DEM), slope angle, and slope aspect thematic layers were used to depict remote sensing data. The landslide susceptibility was extracted from remote sensing thematic data. The elevations of the Al Taif area, which range from 832 to 2,594 m amsl, were identified based on the DEM. Al Taif’s slope angles range from 0° to 67.3° degrees. Nearly flat (0° to 4.75°), moderate (4.75° to 11.1°), steep (11.2° to 29.1°), and very steep slope (≤29.1°) are the different classifications for the slope. Additionally, measurements of the microtremor have been taken at 42 locations throughout the region. The horizontal-to-vertical spectral ratio (HVSR) approach was used to process and analyze microtremor data in order to determine the resonance frequency and H/V amplification factor. The findings show that, while the amplification factor varies from 1.17 to 9.28, the dominant frequency values fall between 0.3 and 12.75 Hz. To determine the frequency, amplitude, and azimuthal site response, 11 sites were eventually chosen. Furthermore, the direction of the site response in the sliding areas was parallel to the landslide directional response, indicating that the site response direction tracked the landslide direction. Practical approval of the study’s findings has been given at a number of locations by field measurements at some of the Taif urban area’s most recent landslide occurrence areas. These findings show that the integration between remote sensing and microtremor measurements is a useful tool for pinpointing landslide-prone areas, which helps to lessen the danger to people’s lives and property. This susceptibility zonation applied to the Al Taif area has produced a good match between the distribution of the reported landslides and the zones of high susceptibility. To define the general trend and geographic distribution of potentially unstable slopes and landslide potential zones, this study’s findings must be used as a guide.

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“…LC with fluorescence detection has also been applied for the same purpose (Cui et al, 2017; Guo et al, 2021; M. He, Wang, & Wei, 2016; Huang et al, 2018; Huo et al, 2014). However, LC tandem mass spectrometry (HPLC–MS/MS) provides higher sensitivity and selectivity (Al Bawab et al, 2020; Alhusban et al, 2021) and has been employed successfully for the determination of various neurotransmitters in brain tissues (Forgacsova et al, 2018; B. He et al, 2013; He, Zhao, et al, 2016; Helmschrodt et al, 2020; Kim et al, 2014; Kuang et al, 2019; Lin et al, 2019; Liu et al, 2018; Nirogi et al, 2010; Olesti et al, 2019; Sørensen & Johannsen, 2019; H. Wang et al, 2012; Wojnicz et al, 2016; Zheng et al, 2017; Zhou et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Rapid and sensitive HPLC–MS/MS method for the quantification of dopamine, GABA, serotonin, glutamine and glutamate in rat brain regions after exposure to tobacco cigarettes

Alhusban

Hammad

Alzaghari

et al. 2022

Biomedical Chromatography

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Tobacco smoking is a preventable main cause of fatal diseases. Accurate measurements of the effects it has on neurotransmitters are essential in developing new strategies for smoking cessation. Moreover, measurements of neurotransmitter levels can aid in developing drugs that counteract the effects of smoking. The aim of this study is to develop and validate a fast, simultaneous and sensitive method for measuring the levels of neurotransmitters in rat brain after the exposure of tobacco cigarettes. The selected neurotransmitters include dopamine, GABA, serotonin, glutamine and glutamate. The method is based on high‐performance liquid chromatography–tandem mass spectrometry. Chromatographic separation was achieved within 3 min using a Zorbax SB C18 column (3.0 × 100 mm, 1.8 μm particle size). The mobile phase consisted of HPLC‐grade water and acetonitrile each containing 0.3% heptafluorobutyric acid and 0.5% formic acid at gradient conditions. The linear range was 0.015–0.07, 825–7,218, 140–520, 63.42–160.75 and 38.25 × 103 to 110.35 × 103 ng/ml for dopamine, GABA, serotonin, glutamine and glutamate, respectively. Inter‐ and intra‐run accuracy were in the range 97.82–103.37% with a precision (CV%) of ≤0.90%. The results revealed that 4 weeks of cigarette exposure significantly increased neurotransmitter levels after exposure to tobacco cigarettes in various brain regions, including the hippocampus and the amygdala. This increase in neurotransmitters levels may in turn activate the nicotine dependence pathway.

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Pharmacokinetics and Bioequivalence Estimation of Two Formulations of Alfuzosin Extended‐Release Tablets

Cited by 8 publications

References 18 publications

A synchronous spectrofluorometric technique for simultaneous detection of alfuzosin and tadalafil: applied to tablets and spiked biological samples

A synchronous spectrofluorometric technique for simultaneous detection of alfuzosin and tadalafil: applied to tablets and spiked biological samples

Landslide susceptibility mapping of Al Taif urban area, Saudi Arabia, using remote sensing data and microtremor measurements: integrated approach

Rapid and sensitive HPLC–MS/MS method for the quantification of dopamine, GABA, serotonin, glutamine and glutamate in rat brain regions after exposure to tobacco cigarettes

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