Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P1231

Han, Limei; Guo, Jie; Zhang, Lijun; Wang, Qingsong; Fang, Xiaoling

doi:10.1111/j.1745-7254.2006.00340.x

Cited by 92 publications

(54 citation statements)

References 22 publications

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“…PEG-bpoly(alkyl acrylate-co-methacrylic acid) micelles entrapping fenofibrate exhibited enhanced oral bioavailability as compared to fenofibrate suspension [261]. Han et al studied the pharmacokinetics and biodistribution of Pluronic P123 micelles loaded with paclitaxel [262]. The effective solubilization of paclitaxel by the micellar core resulted in an increased bioavailability of the drug.…”

Section: F127mentioning

confidence: 99%

Polymeric micelles: authoritative aspects for drug delivery

Kulthe

Choudhari

Inamdar

et al. 2012

Designed Monomers and Polymers

187

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Section: F127mentioning

confidence: 99%

Polymeric micelles: authoritative aspects for drug delivery

Kulthe

Choudhari

Inamdar

et al. 2012

Designed Monomers and Polymers

187

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“…Illum et al demonstrated that it was possible to signiˆcantly alter the in vitro interaction with isolated macrophages and the biodistribution of model polystyrene nanospheres after coating the particle surface with a Pluronic. 9,10) Additionally, we also reported that PTX-loaded Pluronic P123 micelles could eŠectively prolong blood circulation time and modify the biodistribution of PTX in vivo 11) and exert higher cytotoxicity against resistant human ovarian tumor cell line, SKOV-3/ PTX (unpublished data). Previously, we have reported on micellar PTX formulation employing Pluronic P105, and have demonstrated that the micellar PTX could increase the cytotoxicity against MCF-7/ADR, resistant breast tumor cell line.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Biodistribution of Paclitaxel-loaded Pluronic P105/L101 Mixed Polymeric Micelles

Wang

et al. 2008

YAKUGAKU ZASSHI

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A mixed polymeric micelle formulation of paclitaxel (PTX) has been developed with the purpose of improving the solubility and prolonging the time of blood circulation of PTX in comparison to current Taxol injection. The mixed micelles were prepared by thin-ˆlm method using a nonionic surfactant Pluronic P105, L101 and PTX. The mean size of PTX-loaded mixed micelles was 185 nm with narrow size distribution shown by a dynamic light scattering sizer and a transmission electron microscopy. The in vitro release proˆles indicated that PTX release from the mixed micelles exhibited a sustained release behavior. A similar phenomenon was also observed in a pharmacokinetic assessment in rats, in which t 1/2b and AUC of the mixed micelle formulation were 5.5 and 4.9-fold higher than that of Taxol injection. The biodistribution study in mice showed that the PTX-loaded mixed micelles not only decreased drug uptake by liver, but also prolonged drug retention in blood, and increased distribution of the drug in lung, spleen and kidney. These results suggested that the mixed polymeric micelles may e‹ciently load, protect and retain PTX in both in vitro and in vivo environments, and could be a useful drug carrier for intravenous administration of PTX.

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“…Moreover, PMs possess higher drug loading capacity, significantly lower critical micelle concentration values and greater thermodynamic stability than those of low-molecular weight surfactants micelles (Nishiyama & Kataoka, 2006). And the simple preparation process without organic solvents is also one of the important advantages of PMs (Han et al, 2006). Methoxypolyethylenelglycol-distearyl phosphatidyl-ethanolamine (mPEG-DSPE) is generally used to prepare liposomes.…”

Section: Introductionmentioning

confidence: 99%

Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles

et al. 2015

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Context: Transporting drugs through the lymphatic system has attracted increasing attention. Lipid-based formulations have been proved to be an effective way to improve systemic bioavailability of highly lipophilic drugs by increasing intestinal lymphatic transport. Objective: The formulation of polymer micelle was developed for probucol to improve its intestinal lymphatic transport. Materials and methods: Methoxy-polyethylenelglycol-distearyl phosphatidyl-ethanolamine (mPEG-DSPE) polymer was chosen to develop the micelles for probucol. The physicochemical properties were characterized. Caco-2 cell model, unconscious and conscious lymph duct cannulated rat models were established for in vitro and in vivo evaluation of lymphatic transport. Results: In vitro evaluation in the Caco-2 cell model showed that the micellar formulation could significantly increase the uptake and transport of probucol. The study in unconscious and conscious lymph duct cannulated rat models further verified the significant enhancement of lymphatic transport of probucol by mPEG-DSPE micelles. Discussion and conclusion: These results suggested that mPEG-DSPE micellar formulation could provide a useful alternative approach for improving the lymphatic transport of hydrophobic compounds.

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Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with Pluronic P1231

Abstract: Polymeric micelles using Pluronic P123 can effectively solubilize PTX, prolong blood circulation time and modify the biodistribution of PTX.

Cited by 92 publications

References 22 publications

Polymeric micelles: authoritative aspects for drug delivery

Polymeric micelles: authoritative aspects for drug delivery

Pharmacokinetics and Biodistribution of Paclitaxel-loaded Pluronic P105/L101 Mixed Polymeric Micelles

Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles

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