Pharmacokinetics and bioavailability of cefquinome in crossbred wild boars

Influence of the Injection Site on the Pharmacokinetics of Cefquinome Following Intramuscular Injection in Piglets

“…Cefquinome was rapidly and almost completely absorbed (F, 103.04 ± 13.01% vs. 97.56 ± 16.14%, P>0.05) following i.m. injection into two different injection sites, which is consistent with the results in ducks, rabbits, wild boars and sheep [10,14,18,21]. In addition, this result was similar to that in a previous report in piglets after a single i.m.…”

“…This was similar to the findings for other species, the t 1/2λz and Cl of cefquinome ranged from 0.78 to 1.64 hr and 0.18 to 0.34 l/kg/hr in sheep, rabbits, wild boars and duck indicating the rapid elimination of cefquinome after i.v. injection [10,13,14,18,21]. The V ss of cefquinome in this study was 0.25 ± 0.04 l/kg, which was similar to the reported values of 0.23 l/kg in calves, 0.21 l/kg in rabbits and 0.21 l/kg in horses [10,13,19].…”

“…The t 1/2λz of cefquinome after i.m. injection into the neck muscle in this study was 1.57 ± 0.23 vs. 1.56 ± 0.02 hr, which was shorter than what was previously reported in piglets (4.36 ± 2.35 hr), but closer to the values obtained in wild boars (1.41 ± 0.31 hr) [12,14].…”

“…Cefquinome, an aminothiazolyl cephalosporin, is a fourth-generation cephalosporin that has been used employed for veterinary use only [14]. It has broad-spectrum antibacterial activity against clinically important bacteria such as Streptococcus spp., Staphylococcus spp., Pseudomonas spp., Moraxella spp., Haemophilus spp.…”

Integration of PK/PD for dose optimization of Cefquinome against Staphylococcus aureus causing septicemia in cattle

“…This drug has been developed especially for use in veterinary medicine (Smiet et al, 2012; Papich, 2014), and is registered in many countries worldwide. Cefquinome has been used for the treatment of many diseases including acute mastitis, respiratory diseases, food rot in cattle, calf septicemia, metritis-mastitits-agalactia syndrome in sows, foal septicemia and respiratory diseases in horses (Uney et al, 2011; Liu et al, 2012; Dumka et al, 2013; Shan et al, 2014). The advantages of cefquinome include broad spectrum antibacterial activity, stability against β-lactamase, enhanced potency, and bioavailability and the ability to penetrate easily into gram negative bacteria (Dumka et al, 2013).…”