Pharmacokinetics and Anti-Diabetic Studies of Gliclazide Nanosuspension

Sampathi, Sunitha; Prajapati, Shubham; Junnuthula, Vijayabhaskarreddy; Dyawanapelly, Sathish

doi:10.3390/pharmaceutics14091947

Cited by 10 publications

(4 citation statements)

References 82 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 36 , 42 Secondly, nanoaggregate microparticles had the smaller particle size, which is a commonly used strategy to enhance the dissolution properties of poorly water-soluble drugs. 43 , 44 …”

Section: Resultsmentioning

confidence: 99%

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Huang,

Tang,

Meng

et al. 2024

IJN

View full text Add to dashboard Cite

Introduction Nanoparticles have the advantages of improving the solubility of poorly water-soluble drugs, facilitating the drug across biological barriers, and reducing macrophage phagocytosis in pulmonary drug delivery. However, nanoparticles have a small aerodynamic particle size, which makes it difficult to achieve optimal deposition when delivered directly to the lungs. Therefore, delivering nanoparticles to the lungs effectively has become a popular research topic. Methods Nanoaggregate microparticles were used as a pulmonary drug delivery strategy for the improvement of the bioavailability of cyclosporine A (CsA). The nanoaggregate microparticles were prepared with polyvinyl pyrrolidone (PVP) as the excipient by combining the anti-solvent method and spray drying process. The physicochemical properties, aerodynamic properties, in vivo pharmacokinetics and inhalation toxicity of nanoaggregate microparticles were systematically evaluated. Results The optimal nanoparticles exhibited mainly spherical shapes with the particle size and zeta potential of 180.52 nm and −19.8 mV. The nanoaggregate microparticles exhibited irregular shapes with the particle sizes of less than 1.6 µm and drug loading (DL) values higher than 70%. Formulation NM-2 as the optimal nanoaggregate microparticles was suitable for pulmonary drug delivery and probably deposited in the bronchiole and alveolar region, with FPF and MMAD values of 89.62% and 1.74 μm. In addition, inhaled NM-2 had C max and AUC 0-∞ values approximately 1.7-fold and 1.8-fold higher than oral cyclosporine soft capsules (Neoral ® ). The inhalation toxicity study suggested that pulmonary delivery of NM-2 did not result in lung function damage, inflammatory responses, or tissue lesions. Conclusion The novel nanoaggregate microparticles for pulmonary drug delivery could effectively enhance the relative bioavailability of CsA and had great potential for clinical application.

show abstract

Section: Resultsmentioning

confidence: 99%

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Huang,

Tang,

Meng

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

“…The surface topology of gold nanoparticles and coated and plain sutures (PSs) was determined using SEM (Hitachi High-Tech Corporation, Tokyo, Japan S-3700N) at a voltage of 30 kV with 500–10,000× magnification [ 52 , 53 ].…”

Section: Methodsmentioning

confidence: 99%

Development of Biocompatible Ciprofloxacin–Gold Nanoparticle Coated Sutures for Surgical Site Infections

et al. 2022

View full text Add to dashboard Cite

Surgical site infections (SSIs) are mainly observed after surgeries that use biomaterials. The aim of this present work was to develop ciprofloxacin hydrochloride (CPH)-loaded gold nanoparticles. These ciprofloxacin–gold nanoparticles were coated onto a sterile surgical suture using an adsorption technique, followed by rigidization via ionotropic crosslinking using sodium alginate. Furthermore, UV-visible spectroscopy, infrared spectroscopy, and scanning electron microscopy were used to characterize the samples. The particle size of the nanoparticles was 126.2 ± 13.35 nm with a polydispersity index of 0.134 ± 0.03, indicating nanosize formation with a monodispersed system. As per the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines, stability studies were performed for 30 days under the following conditions: 2–8 °C, 25 ± 2 °C/60 ± 5% RH, and 40 ± 2 °C/75 ± 5% RH. For both Gram-negative and Gram-positive bacteria, the drug-coupled nanoparticle-laden sutures showed a twofold higher zone of inhibition compared with plain drug-coated sutures. In vitro drug release studies showed a prolonged release of up to 180 h. Hemolysis and histopathology studies displayed these sutures’ acceptable biocompatibility with the healing of tissue in Albino Swiss mice. The results depict that the use of antibiotic-coated sutures for preventing surgical site infection for a long duration could be a viable clinical option.

show abstract

“…This design has three advantages: (i) having three levels that can be coded as −1 (low), 0 (middle), and +1 (high), (ii) creating an independent quadratic design, (iii) providing an easier way to interpret the results, and (iv) providing enough data to fit quadratic models for various applications [18,19]. For example, BBD is widely used in bioengineering processes to optimize environmental factors [20], operational factors [21], and formulation factors [22] because it can decrease the number of experimental sets.…”

Section: Introductionmentioning

confidence: 99%

Biological Activities of Citrus aurantium Leaf Extract by Optimized Ultrasound-Assisted Extraction

Wang,

Huang,

Huang

et al. 2023

Molecules

View full text Add to dashboard Cite

Several studies have explored the biological activities of Citrus aurantium flowers, fruits, and seeds, but the bioactivity of C. aurantium leaves, which are treated as waste, remains unclear. Thus, this study developed a pilot-scale ultrasonic-assisted extraction process using the Box–Behnken design (BBD) for the optimized extraction of active compounds from C. aurantium leaves, and their antityrosinase, antioxidant, antiaging, and antimicrobial activities were evaluated. Under optimal conditions in a 150× scaleup configuration (a 30 L ultrasonic machine) of a pilot plant, the total phenolic content was 69.09 mg gallic acid equivalent/g dry weight, which was slightly lower (3.17%) than the theoretical value. The half maximal inhibitory concentration of C. aurantium leaf extract (CALE) for 2,2-diphenyl-1-picrylhydrazyl–scavenging, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)–scavenging, antityrosinase, anticollagenase, antielastase and anti-matrix metalloprotein-1 activities were 123.5, 58.5, 181.3, 196.4, 216.3, and 326.4 mg/L, respectively. Moreover, the minimal inhibitory concentrations for bacteria and fungi were 150–350 and 500 mg/L, respectively. In total, 17 active compounds were detected in CALE—with linalool, linalyl acetate, limonene, and α-terpineol having the highest concentrations. Finally, the overall transdermal absorption and permeation efficiency of CALE was 95.9%. In conclusion, our CALE demonstrated potential whitening, antioxidant, antiaging, and antimicrobial activities; it was also nontoxic and easily absorbed into the skin as well as inexpensive to produce. Therefore, it has potential applications in various industries.

show abstract

Pharmacokinetics and Anti-Diabetic Studies of Gliclazide Nanosuspension

Cited by 10 publications

References 82 publications

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Development of Biocompatible Ciprofloxacin–Gold Nanoparticle Coated Sutures for Surgical Site Infections

Biological Activities of Citrus aurantium Leaf Extract by Optimized Ultrasound-Assisted Extraction

Contact Info

Product

Resources

About