Pharmacokinetics &amp; tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia

Al-Jamal, Wafa' T; Al-Ahmady, Zahraa S.; Kostarelos, Kostas

doi:10.1016/j.biomaterials.2012.03.018

Cited by 98 publications

(103 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Splenic uptake is often compared to a filtering or a sieving process, particularly effective to remove poorly opsonized antigens, therefore it does not depend on the nanoparticles surface properties (47). The spleen uptake of 5-FU-NTSLs compared to 5-FU-TSLs at 4 h is significantly higher by 1.5-fold in agreement with previous published data (28). Schroit et al report that CHOL increases the uptake of PC liposomes by the RES (48).…”

Section: Discussionsupporting

confidence: 87%

“…The biodistribution (BD) of the three formulations mentioned above was followed only at time points 4 and 24 h after injection since liposomes exhibit a cumulative deposition in organs at earlier time points (28,29). After blood withdrawal, lungs, liver, spleen, kidneys, tumor and bone marrow were excised and mice were humanely sacrificed subsequently.…”

Section: Biodistribution Study In Tumor-bearing Micementioning

confidence: 99%

See 1 more Smart Citation

Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Biodistribution Study In Tumor-bearing Micementioning

confidence: 99%

Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil

et al. 2014

View full text Add to dashboard Cite

show abstract

“…LipoICG 75 provided an intense signal congruent with vascular structures identified on the anatomical image within the first minutes after injection. This is consistent with the previously reported pharmacokinetic profile of PEGylated liposomes [31] and indicated that LipoICG 75 at the early time points post-administration remained confined within the vascular system and did not localize within other tissues or deoxygenated regions of limited blood supply. At later time points, accumulation of the liposomes in the center of the 4T1 tumor can be observed (Fig.…”

Section: Lipoicg 75 Behavior In Tumor Bearing Animalssupporting

confidence: 93%

“…2C). The observed tissue distribution data, even though not quantitative, were in agreement with previously published quantitative data using radiolabelled PEGylated liposomes [30,31], further indicating the validity of MSOT imaging.…”

Section: Lipoicg Tissue Distribution By Nir Fluorescence (Ivis) and Osupporting

confidence: 93%

Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT)

et al. 2015

Self Cite

View full text Add to dashboard Cite

“…Because the antitumor activity of the DOX delivery system on melanoma has been demonstrated, 27,[41][42][43] in the present study we selected DOX as a model drug to prepare the iRGD-SSL-DOX. The antitumor activity of iRGD-SSL-DOX was evaluated in a B16-F10 bearing animal model.…”

mentioning

confidence: 99%

The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation

Yu¹,

Zhang²,

Luo³

et al. 2013

IJN

View full text Add to dashboard Cite

Considering the fact that iRGD (tumor-homing peptide) demonstrates tumor-targeting and tumor-penetrating activity, and that B16-F10 (murine melanoma) cells overexpress both αv integrin receptor and neuropilin-1 (NRP-1), the purpose of this study was to prepare a novel doxorubicin (DOX)-loaded, iRGD-modified, sterically-stabilized liposome (SSL) (iRGD-SSL-DOX) in order to evaluate its antitumor activity on B16-F10 melanoma cells in vitro and in vivo. The iRGD-SSL-DOX was prepared using a thin-film hydration method. The characteristics of iRGD-SSL-DOX were evaluated. The in vitro leakage of DOX from iRGD-SSL-DOX was tested. The in vitro tumor-targeting and tumor-penetrating characteristics of iRGD-modified liposomes on B16-F10 cells were investigated. The in vivo tumor-targeting and tumor-penetrating activities of iRGD-modified liposomes were performed in B16-F10 tumor-bearing nude mice. The antitumor effect of iRGD-SSL-DOX was evaluated in B16-F10 tumor-bearing C57BL/6 mice in vivo. The average particle size of the iRGD-SSL-DOX was found to be 91 nm with a polydispersity index (PDI) of 0.16. The entrapment efficiency of iRGD-SSL-DOX was 98.36%. The leakage of DOX from iRGD-SSL-DOX at the 24-hour time point was only 7.5%. The results obtained from the in vitro flow cytometry and confocal microscopy, as well as in vivo biodistribution and confocal immunofluorescence microscopy experiments, indicate that the tumor-targeting and tumor-penetrating activity of the iRGD-modified SSL was higher than that of unmodified SSL. In vivo antitumor activity results showed that the antitumor effect of iRGD-SSL-DOX against melanoma tumors was higher than that of SSL-DOX in B16-F10 tumor-bearing mice. In conclusion, the iRGD-SSL-DOX is a tumor-targeting and tumor-penetrating peptide modified liposome which has significant antitumor activity against melanoma tumors.

show abstract

Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia

Cited by 98 publications

References 42 publications

Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil

Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil

Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT)

The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation

Contact Info

Product

Resources

About