Pharmacokinetic study of oxytetracycline in healthy and vibriosis-infected ayu (Plecoglossus altivelis)

Antibacterial Agents in Mediterranean Finfish Farming: A Synopsis of Drug Pharmacokinetics in Important Euryhaline Fish Species and Possible Environmental Implications

“…This is to address (in addition to reduced fish appetite) the possibility of reduced capacity in infected animals to absorb and metabolize the drug, which must be taken into consideration when treatment regimens are designed. For example, Uno (1996) demonstrated significant differences in absorption of oxytetracycline (OTC) after oral administration between vibrioinfected and healthy ayu (Plecoglossus altivelis). Bioavailability of OTC was reduced by 60% in infected fish with both plasma and tissue levels considerably lower, compared to healthy fish.…”

Lack of gender effect on the pharmacokinetics of oxytetracycline in Fenneropenaeus chinensis after intramuscular administration

“…The apparent volume of OTC distribution in F. chinensis was much bigger than that in carp (2.1 L kg −1 , Grondel et al, 1987), rainbow trout (2.1 L kg −1 , Grondel et al, 1989), ayu (1.3 L kg −1 , Uno, 1996), swine (1.7 L kg −1 , Liu et al, 2011), and rabbit (1.99 L kg −1 , Marín et al, 2013), but smaller than that in lactating goats (16.1 L kg −1 , Amer et al, 2012). Thus, the organotropy of OTC in F. chinensis is higher than that in carp, rainbow trout, ayu, swine and rabbit, but lower than that in lactating goats.…”

“…In the present study, total body clearance of OTC in F. chinensis was estimated to be 157-172 mL kg −1 h −1 (Table 1), approximately 10-fold higher than those reported in other species. Uno (1996), Grondel et al (1987) and Grondel et al (1989) estimated the total body clearance to be 17.4 mL kg −1 h −1 in ayu, 10.2 mL kg −1 h −1 in carp, 16.2 mL kg −1 h −1 in rainbow trout, and 11.4 mL kg −1 h −1 in African catfish. The results suggest that F. chinensis clear drugs at a faster rate than ayu, carp, rainbow trout and African catfish.…”

“…Of these, OTC is one of the antibiotics most widely used against vibriosis and furunculosis (Uno, 1996). The mode of OTC action is to interfere with bacterial protein synthesis by binding to bacterial 30S ribosomal subunit (Rigos et al, 2003).…”

Residual pharmaceutically active compounds (PhACs) in aquatic environment - status, toxicity and kinetics: a review

“…Furthermore, in crustaceans the volume of haemolymph comprises 22% of the total body weight, compared to 5% in finfish (Barron et al, 1988;Plakas et al, 1990), with the volume of distribution directly related to tissue binding and inversely related to plasma protein binding. Protein binding in finfish is always higher than that found in crustaceans, e.g., 23 and 14-21% in P. japonicus (Uno, 2004) and P. setiferus (Reed et al, 2004), respectively, compared to 51-55% in O. mykiss (Bjorklund and Bylund, 1991;Uno et al, 1997) and 68% in P. altivelis (Uno, 1996). A diminished binding of plasma protein results in an increase in extravascular distribution.…”