Pharmacokinetic study of adverse effects in offspring caused by prenatal Bisphenol F exposure

Iwano, Hidetomo; Ohtani, Naoko; Hozumi, Noriko; Inoue, Hiroki; Yokota, Hiroshi

doi:10.1016/j.toxlet.2016.07.288

Cited by 3 publications

(2 citation statements)

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“…BPF can be converted to conjugated metabolites (BPF-glucuronide, BPF-sulfate and BPF-glucuronide/sulfate) in the maternal liver of a tissue perfusion model and eliminated from the body. BPF sulfate can easily passed to the embryo through the placenta (Iwano, Hozumi, Inoue, & Yokota, 2016).…”

Section: Plastic Compounds: Cellular and Biochemical Effectsmentioning

confidence: 99%

Plastics derived endocrine‐disrupting compounds and their effects on early development

Basak

Das

Duttaroy

2020

Birth Defects Research

103

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Despite the fact that the estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. The adverse health effects of plastics recommend to measure the impacts of endocrine-disrupting compounds (EDCs) such as bisphenols (BPA, BPS, BPF), bis(2-ethylhexyl) phthalate, and dibutyl phthalate (DBP) in human health. Exposure to these compounds in utero may program the diseases of the testis, prostate, kidney and abnormalities in the immune system, and cause tumors, uterine hemorrhage during pregnancy and polycystic ovary. These compounds also control the processes of epigenetic transgenerational inheritance of adult-onset diseases by modulating DNA methylation and epimutations in reproductive cells. The early developmental stage is the most susceptible window for developmental and genomic programming. The critical stages of the events for a normal human birth lie between the many transitions occurring between spermatogenesis, egg fertilization and the fully formed fetus. As the cells begin to grow and differentiate, there are critical balances of hormones, and protein synthesis. Data are emerging on how these plastic-derived compounds affect embryogenesis, placentation and feto-placental development since pregnant women and unborn fetuses are often exposed to these factors during preconception and throughout gestation. Impaired early development that ultimately influences fetal outcomes is at the center of many developmental disorders and contributes an independent risk factor for adult chronic diseases. This review will summarize the current status on the impact of exposure to plastic derived

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Section: Plastic Compounds: Cellular and Biochemical Effectsmentioning

confidence: 99%

Plastics derived endocrine‐disrupting compounds and their effects on early development

Basak

Das

Duttaroy

2020

Birth Defects Research

103

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“…In a rat study from 2006, BPF residues were detected in the uterus, placenta, amniotic fluid and fetuses, and the levels of BPF in the intrauterine compartment and maternal blood were comparable (Cabaton et al 2006). Iwano et al (2016) reported that BPF is metabolized to conjugated metabolites (BPF-glucuronide, BPF-sulfate and BPF-glucuronide/ sulfate) in the maternal liver of a tissue perfusion model. BPF sulfate was easy to pass to the embryo through the placenta.…”

Section: Alternative Bisphenolsmentioning

confidence: 99%

Prenatal Exposure to Bisphenols and Parabens and Impacts on Human Physiology

Kolátorová

Dušková²,

Vítků³

et al. 2017

Physiol Res

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In modern societies, living organisms are exposed daily to multiform pollution from industrial chemical products. Some of these substances have been shown to affect the endocrine system, and have been termed endocrine disruptors (EDs). Bisphenol A (BPA), which can leach from plastics, and parabens, used in cosmetic products, are among the most well-studied. Prenatal development is a vulnerable phase of human life, and disruptions during this period may have lifelong consequences. Since EDs are known to cross the placental barrier and BPA may accumulate in the fetus, “BPA-free” products have been introduced to the market. However, such products often contain alternative bisphenols (e.g. BPS, BPF) that have not yet been extensively examined or regulated. Moreover, alternative bisphenols often occur together with BPA. The human organism is thus exposed to a mixture of EDs, some of which can have additive or synergic effects. Recent findings have also shown that paraben exposure can alter bisphenol pharmacokinetics. Taking into account the widespread occurrence of various EDs and the potential multiplicity of their effects, doses of EDs currently considered safe may not actually be as safe as they appear, especially during pregnancy.

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Exposure to bisphenols and parabens during pregnancy and relations to steroid changes

Kolátorová

Vítků

Hampl

et al. 2018

Environmental Research

108

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Pharmacokinetic study of adverse effects in offspring caused by prenatal Bisphenol F exposure

Cited by 3 publications

References 0 publications

Plastics derived endocrine‐disrupting compounds and their effects on early development

Plastics derived endocrine‐disrupting compounds and their effects on early development

Prenatal Exposure to Bisphenols and Parabens and Impacts on Human Physiology

Exposure to bisphenols and parabens during pregnancy and relations to steroid changes

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