Pharmacokinetic studies of meloxicam after its intravenous administration in local goat (Capra hircus) of Assam

Abstract

Aim: The aim of the present study was to determine the meloxicam concentrations in the plasma of goats at different time intervals after its administration by IV route and data were used to determine the different pharmacokinetic parameters and the bioavailability of meloxicam in goats. Materials and Methods:The present study was conducted on 12 to 18 months old, five adult male local goats (Capra hircus) of Assam, with body weight ranging between 10 to 18 kg. All goats were clinically sound and healthy and reared at Goat Research station, Burnihat, Assam. A single dose of meloxicam was administered intravenously into the jugular vein of goats at the rate of 1 mg/kg body weight. Blood samples were analyzed with the help of high performance liquid chromatography (HPLC) system.Results:After single intravenous administration of meloxicam at the dose rate of 1mg/kg, the mean peak plasma level of the drug was 6.538±0.1189 µg/ml at 2 min. The mean elimination half life (t ) and mean distribution half life (t ) were Conclusion:After calculating various pharmacokinetic determinants, dosage regimens were computed for meloxicam in goats, based on minimum effective therapeutic plasma concentration of 0.7 µg/ml.To maintain the minimum effective concentration of 0.7 µg/ml in plasma for 25 hours following iv administration of meloxicam,an initial loading dose of 1.1 mg/kg body weight followed by a maintenance dose of 1mg/kg body weight/day is recommended.

Pharmacokinetics of meloxicam in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections

“…1,7 Meloxicam is a COX-2 selective NSAID that has been used extensively for its anti-inflammatory, analgesic, and antipyretic activity in some domestic animal species. [8][9][10][11] The pharmacokinetics of meloxicam has been evaluated in several species, including baboons, a mice, a horses, 12,13 donkeys, 13 sheep, 14,15 goats, 14,16,17 cattle, 18,19 dogs, 20,21,a vultures, 22 green iguanas, 23 cats, 24,25 piglets, 26,a camels, 27 llamas, 28 and rabbits. [29][30][31] Because no data are available for red-eared slider turtles (Trachemys scripta elegans), the dosage of meloxicam used in that species is routinely extrapolated from dosages for other species (ie, 0.1 to 0.2 mg/ kg, q 24 to 48 h).…”

Effect of castration procedure on the pharmacokinetics of meloxicam in goat kids

“…In Canada, the use of meloxicam at an oral dose of 1 mg/kg in castration has been approved (Melendez et al., 2019). The dose of meloxicam recommended by European Medicines Agency (EMA) for use in goats is 0.5 mg/kg, whereas some studies have recommended the dose of 1 mg/kg (CVMP, 2006; Wani, Roy, Ashraf, & Roy, 2013). Meloxicam at doses of 1 and 2 mg/kg is quite effective in a sheep inflammation model (Colditz, Paull, Lloyd, Johnston, & Small, 2019; Woodland et al., 2019).…”

“…The minimum plasma concentration of meloxicam required for therapeutic effect in goats is 0.07 μg/ml (Wani et al, 2013). The effective plasma concentration (EC 50 ) of meloxicam for antipyretic and analgesic effects is 0.21 and 0.39 μg/ml, respectively, in the paw inflammation model in dogs and that for stride length and lameness are 0.13 and 0.2 μg/ml, respectively, in the arthritis model in horses (Jeunesse et al., 2011; Toutain & Cester, 2004).…”

Pharmacokinetics and relative bioavailability of meloxicam oil suspension in pigs after intramuscular administration

“…There were few data reported in the literature regarding the intramuscular administration route of MEL in pigs, but studies have been carried out on the pharmacokinetics of MEL via intravenous administration extensively, and results showed that the t 1/2λz of MEL in plasma were 2.7 hr (0.4 mg/kg) in pigs (Fosse et al, ); 20.35 hr (0.5 mg/kg) and 21.86 hr (0.5 mg/kg) in calves (Coetzee, Kukanich, Kukanich, Mosher, & Allen, ; Coetzee et al, ); 5.29 hr (0.5 mg/kg) in horses (Pierre‐Louis & Cester, ); 8.08 hr (1 mg/kg), 6.73 hr (0.5 mg/kg), and 9.96 hr (0.5 mg/kg) in goats (De Vito et al, ; Shukla et al, ; Wani, Roy, Roy, Ashraf, & Roy, ); 11.54 hr (0.1 mg/kg) in beagle dogs (Junyi Hao & Cao, ); 3. 69 hr (1.5 mg/kg) in guinea pigs (Moeremans, Devreese, Devreese, Baere, Croubels, & Hermans, ); and 6.41 hr (10 mg/kg) in mice (Busch et al, ), revealing great interspecific variability.…”

“…(1 mg/kg), 6.73 hr (0.5 mg/kg), and 9.96 hr (0.5 mg/kg) in goats (De Vito et al, 2018;Shukla et al, 2007;Wani, Roy, Roy, Ashraf, & Roy, 2013); 11.54 hr (0.1 mg/kg) in beagle dogs (Junyi Hao & Cao, 2017);…”