Pharmacokinetic Studies in Liver Cirrhosis �Further Advances

Okolicsanyi, L; Strazzabosco, Mario; Orlando, Rocco; Venuti, M.; Berti, T

doi:10.1159/000412235

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“…The signifi cantly higher AUC values seen in cirrhotic patients suggest a decreased biotransfor- mation of the drug, similarly to that re ported for other two macrolides: josamycin and erythromycin [2][3][4][5]. However, since there is no proportional lengthening of the half-life of miocamycin, the in crease in AUC appears mainly due to a de creased presystemic metabolism, which could be related to the presence of porto systemic shunts.…”

Section: Discussionmentioning

confidence: 82%

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Pharmacokinetics of Miocamycin in Patients with Liver Cirrhosis

Miglioli

Pivetta²,

Orlando³

et al. 1989

Chemotherapy

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Section: Discussionmentioning

confidence: 82%

“…In chronic liver diseases the disposition of some macrolide antibiotics, such as josamycin and erythromycin is altered [2][3][4][5]. The kinetics of miocamycin in cirrhotics is not yet known.…”

Section: Introductionmentioning

confidence: 99%