Pharmacokinetic studies in children with cancer

Groninger, Ellis; Proost, Johannes H.; Graaf, Siebold S.N. de

doi:10.1016/j.critrevonc.2004.08.007

Cited by 39 publications

(28 citation statements)

References 180 publications

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“…The thiopurine antimetabolites 6-thioguanine and 6-mercaptopurine are important chemotherapeutic drugs in the treatment of childhood acute lymphoblastic leukaemia [103][104][105]. Measurement of metabolites of these thiopurines is important because correlations exist between their concentration and the prognosis in childhood acute lymphoblastic leukemia.…”

Section: Thiopurinesmentioning

confidence: 99%

Determination of endogenous thiols and thiol drugs in urine by HPLC with ultraviolet detection

Kuśmierek

Chwatko

Głowacki

et al. 2009

Journal of Chromatography B

123

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Section: Thiopurinesmentioning

confidence: 99%

Determination of endogenous thiols and thiol drugs in urine by HPLC with ultraviolet detection

Kuśmierek

Chwatko

Głowacki

et al. 2009

Journal of Chromatography B

123

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“…Ifosfamide ( (Groninger et al, 2004). In adults it is less common as first-line treatment (except for soft-tissue sarcoma).…”

Section: Ifosfamidementioning

confidence: 99%

“…CYP3A4-mediated hydroxylation and subsequent spontaneous degradation result in the activation of the alkylating agent isophosphoramide mustard and another CYP3A4-mediated route yields the inactive metabolites 2-and 3-dechloroethylifosfamide and an equimolecular quantity of the metabolite chloroacetaldehyde which is supposed to be neuro-and nephrotoxic (Groninger et al, 2004;Zhang et al, 2006).…”

Section: Ifosfamidementioning

confidence: 99%

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Alkylating Agents

Francisco¹,

Perry²,

Moreira³

et al. 2008

Anticancer Therapeutics

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“…The use of medication by children suffering from malignancies constitutes only a small percentage of total medication prescribed for the total population [29]. An additional peculiarity of paediatric oncology is that many cytotoxic drugs are used with very limited data in respect to pharmacokinetics [30]. It is also sometimes even doubtful whether there is activity in combination chemotherapy for an individual drug [31].…”

Section: Figurementioning

confidence: 99%

Licensing and labelling of drugs in a paediatric oncology ward

Berg

Tak

2011

Brit J Clinical Pharma

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WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• High percentages of off-label and unlicensed drug use are common in paediatrics.• Data in paediatric oncology patients hardly exist.• Extemporaneously prepared formulations are common. WHAT THIS STUDY ADDS• Off-label and unlicensed use is substantially higher for cytostatic drugs in paediatric as compared with adult oncology.• Comparison with other paediatric reports on drug use cannot be made due to different percentages of diseases in the reports and other rules to dispense medication in the out-patient setting.• There is an urgent need for suitable formulations, licensing of dosages and provision of data on safety and efficacy in children with malignancies. AIMPaediatric drug prescriptions are known for their high percentages of off-label and unlicensed use. In paediatric oncology data available are scarce. The aim of this paper is an analysis of the licensing and labelling status of all prescribed medication over a 2 week period in a Dutch paediatric oncology centre. METHODSAn analysis of the delivery of medication by the hospital pharmacy to patients admitted to the paediatric oncology centre was carried out. RESULTSIn total 268 precriptions were filed for 39 patients. In 87% of children unlicensed medication was used. Fifty-nine per cent of the children received at least two unlicensed drugs. In total 72% of the drugs were used licensed and on-label was found in 57% of the prescriptions. There was a trend that in younger children percentages were lower. International and local guidelines necessitated in many cases unlicensed use, e.g. intrathecal prednisolone, low dose medication such as heparin, ethanol and vancomycin for locking intravenous devices and higher intravenous vancomycin dosages. There were no major differences with respect to type of malignancy. CONCLUSIONOur figures are substantially higher than the figures reported from adult oncology. Comparison with other paediatric reports are cumbersome, due to different percentages of diseases in the reports and other rules to dispense medication in the outpatient setting. Our data are in line with reports mentioning the higher percentages of unlicensed and off-label use. Our data further underpin the need for more research on suitable formulations, dosages, safety and efficacy in these children.

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Pharmacokinetic studies in children with cancer

Cited by 39 publications

References 180 publications

Determination of endogenous thiols and thiol drugs in urine by HPLC with ultraviolet detection

Determination of endogenous thiols and thiol drugs in urine by HPLC with ultraviolet detection

Alkylating Agents

Licensing and labelling of drugs in a paediatric oncology ward

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