Pharmacokinetic Properties of Rosuvastatin After Single-Dose, Oral Administration in Chinese Volunteers: A Randomized, Open-Label, Three-Way Crossover Study

Effects of statins in an indomethacin-induced gastric injury model in rats

“…We found no published study related to the effects of rosuvastatin on experimental gastric injury. In one publication, it was reported that a 20 mg dose of rosuvastatin caused nausea in three of the 12 patients who participated in the study (19).…”

Development and validation of a sensitive U-HPLC–MS/MS method with electrospray ionization for quantitation of ranolazine in human plasma: Application to a clinical pharmacokinetic study

“…Recently, two LC-MS methods with selected ion monitoring (SIM) have been published [6,7]; both of them allowed the quantitation of ranolazine in rat plasma with the lower limit of quantitation (LLOQ) above 20 ng mL −1 and relatively long HPLC/MS analysis time (6 or 7 min per sample) [8]. Although LC-MS/MS methods have been reported for the analysis of ranolazine in plasma, but the lower limit of quantitation can not meet the requirements for our pharmacokinetic studies and also sample pre-treatment procedure with solid-phase extraction (SPE) procedure or liquid-liquid extraction was time-consuming [9][10][11].…”

Rabdomiólise após exercício físico não intenso

“…A study with 12 Chinese volunteers (six men) who used in single doses 5, 10, 20mg of RO being its tolerability tested from zero hour and after that every hour until 72h. Two cases in the dose of 10mg presented bilirubin increase from 16.1 to 31.4mmolL and another of CK from 141U/L to 307U/L, with return to normal values after Five days and asymptomatic, with-out important myalgias clinical consequences referred (19) . (20) .…”