Pharmacokinetic profiles of the two major active metabolites of metamizole, 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), after intravenous injection in cats

Studies on Photophysical and Biological Activity of Newly Synthesized of 4-Methylpiperidin-4-ol Substituted Pyrazole Derivatives

“…The crude products were further purified by washing with diethyl ether. Finally, to prepare compound (6), 1 mmol of compound (5) was taken in THF (20 ml), and 1.5 mmol of Grignard reagent was added at 0ºC. After the reaction was complete, the mixture was allowed to reach room temperature.…”

“…It is recommended to take dichloralphenazone to treat tension and vascular headaches [5]. Metamizole has been effectively employed for perioperative pain, cancerrelated pain, acute injuries, and various other types of pain, being considered one of the most potent antipyretic agents [6]. Furthermore, several investigational small molecules containing the pyrazolone structure are under consideration as potential drug candidates, including sulfamazone [7], propyphenazone [8], and nifenazone [9].…”