Pharmacokinetic-Pharmacodynamic Relationship of Dobutamine and Heart Rate, Stroke Volume and Cardiac Output in Healthy Volunteers

Ahonen, Jouni; Aranko, Kari; Iivanainen, A. M.; Maunuksela, Eeva‐Liisa; Paloheimo, Markku; Olkkola, Klaus T.

doi:10.2165/00044011-200828020-00006

Cited by 24 publications

(13 citation statements)

References 14 publications

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“…The peripheral vasodilation, indicated by a decrease in SVR, combined with an increase in CO and SV positively influenced local blood flow in this experiment. Previous studies in anaesthetised horses , cats and man using comparable doses, showed similar results regarding systemic haemodynamic parameters. In terms of altering local mesenterial blood flow or oxygen delivery, previous studies in hypotensive foals or experimental models of sepsis failed to show a significant influence on the gastrointestinal perfusion, although jejunal mucosal blood flow has been shown to improve after cardiac surgery with dobutamine infused at 2.7 ± 0.1 μg/kg bwt/min .…”

Section: Discussionsupporting

confidence: 72%

Effects of dobutamine, dopamine, phenylephrine and noradrenaline on systemic haemodynamics and intestinal perfusion in isoflurane anaesthetised horses

Dancker

Hopster

Rohn

et al. 2017

Equine Veterinary Journal

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Section: Discussionsupporting

confidence: 72%

Effects of dobutamine, dopamine, phenylephrine and noradrenaline on systemic haemodynamics and intestinal perfusion in isoflurane anaesthetised horses

Dancker

Hopster

Rohn

et al. 2017

Equine Veterinary Journal

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“…For both temperature conditions, dobutamine resulted in elevated HR consistent with previous findings [27,28]. The hypothermic condition resulted in a slightly larger increase in HR of 29% compared to an increase of 23% in the hyperthermic condition, likely due to an increase in baseline heart rate at 38 °C [19,29].…”

Section: Discussionsupporting

confidence: 88%

Assessing structural and functional response of murine vasculature to acute β-adrenergic stimulation in vivo during hypothermic and hyperthermic conditions

Crouch

Castle

FitzGerald

et al. 2019

International Journal of Hyperthermia

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Background: Because of the importance of adrenoreceptors in regulating the cardiovascular (CV) system and the role of the CV system in thermoregulation, understanding the response to these two stressors is of interest. The purpose of this study was to assess changes of arterial geometry and function in vivo during thermal and β-adrenergic stress induced in mice and quantified by MRI. Methods: Male mice were anesthetized and imaged at 7T. Anatomical and functional data were acquired from the neck (carotid artery), torso (suprarenal and infrarenal aorta and iliac artery), and periphery (femoral artery). Intravenous dobutamine (tail vein catheter, 40 μg/kg/min, 0.12 mL/hr) was used as β-adrenergic stressor. Baseline and dobutamine data were acquired at minimally hypothermic (35°C) and minimally hyperthermic (38°C) core temperatures. Cross-sectional vessel area and maximum cyclic strain were measured across the cardiac cycle. Results: Vascular response varied by location and by core temperature. For minimally hypothermic conditions (35°C), average, maximum, and minimum areas decreased with dobutamine only at the suprarenal aorta (avg: −17.9%, max: −13.5%, min: −21.4%). For minimally hyperthermic conditions (38°C), vessel areas decreased between baseline and dobutamine at the carotid (avg: −19.6%, max: −15.5%, min: −19.3%) and suprarenal aorta (avg: −24.2%, max: −17.4%, min: −17.3%); whereas, only the minimum vessel area decreased for the iliac artery (min: −14.4%). Maximum cyclic strain increased between baseline and dobutamine at the iliac artery for both conditions and at the suprarenal aorta at hyperthermic conditions. Conclusion: At hypothermic conditions the vessel area response to dobutamine is diminished compared to hyperthermic conditions where the vessel area response mimics normothermic dobutamine conditions. The varied response emphasizes the need to monitor and control body temperature during medical conditions or treatments that may be accompanied by hypothermia, especially when vasoactive agents are used.

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“…In healthy volunteers, increasing the dose of dobutamine results in elevated cardiac output, which is linearly related to its plasma concentrations. ( 13 ) The relationships between heart rate and stroke volume to plasma concentrations, however, are more complex. Heart rate initially remains unchanged and then increases with higher concentrations, while stroke volume only increases at lower concentrations.…”

Section: Effects Of Dobutamine In Normal Subjectsmentioning

confidence: 99%

“…In these circumstances, the augmentation in cardiac output goes together with elevations in blood pressure. ( 11 - 13 )…”

Section: Effects Of Dobutamine In Cardiac Failurementioning

confidence: 99%

The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients

Dubin¹,

Lattanzio²,

Gatti³

2017

Revista Brasileira De Terapia Intensiva

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Dobutamine is the inotrope most commonly used in septic shock patients to increase cardiac output and correct hypoperfusion. Although some experimental and clinical studies have shown that dobutamine can improve systemic and regional hemodynamics, other research has found that its effects are heterogenous and unpredictable. In this review, we analyze the pharmacodynamic properties of dobutamine and its physiologic effects. Our goal is to show that the effects of dobutamine might differ between healthy subjects, in experimental and clinical cardiac failure, in animal models and in patients with septic shock. We discuss evidence supporting the claim that dobutamine, in septic shock, frequently behaves as a chronotropic and vasodilatory drug, without evidence of inotropic action. Since the side effects are very common, and the therapeutic benefits are unclear, we suggest that dobutamine should be used cautiously in septic shock. Before a definitive therapeutic decision, the efficacy and tolerance of dobutamine should be assessed during a brief time with close monitoring of its positive and negative side effects.

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Pharmacokinetic-Pharmacodynamic Relationship of Dobutamine and Heart Rate, Stroke Volume and Cardiac Output in Healthy Volunteers

Cited by 24 publications

References 14 publications

Effects of dobutamine, dopamine, phenylephrine and noradrenaline on systemic haemodynamics and intestinal perfusion in isoflurane anaesthetised horses

Effects of dobutamine, dopamine, phenylephrine and noradrenaline on systemic haemodynamics and intestinal perfusion in isoflurane anaesthetised horses

Assessing structural and functional response of murine vasculature to acute β-adrenergic stimulation in vivo during hypothermic and hyperthermic conditions

The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients

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