Pharmacokinetic/pharmacodynamic (PK/PD) considerations in the management of Gram-positive bacteraemia

Scaglione, Francesco

doi:10.1016/j.ijantimicag.2010.11.011

Cited by 15 publications

(14 citation statements)

References 100 publications

(77 reference statements)

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“…However, in order to interpret these results correctly, pharmacodynamic (PD) considerations should also be taken into account. The time that free antimicrobial concentrations remain above the MIC of the infecting pathogen is the PK/ PD index that correlates with bacterial killing and microbiological response for ß-lactams [39][40][41]. Few clinical trials on antimicrobial prophylaxis in surgery have attempted to correlate the rates of infection with the levels of drug in the serum and the duration of inhibitory or bactericidal concentration.…”

Section: Discussionmentioning

confidence: 99%

Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery

Isla

Trocóniz

Tejada

et al. 2012

Eur J Clin Pharmacol

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Section: Discussionmentioning

confidence: 99%

Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery

Isla

Trocóniz

Tejada

et al. 2012

Eur J Clin Pharmacol

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“…Antibiotikoen efektua aurreikusteko hiru deskribatu dira (6. irudia). Alde batetik, kontzentrazio plasmatikoak MIC balioaren gainetik mantentzen diren denbora (T >MIC ); bestetik, antibiotikoaren kontzentrazio maximoaren eta MICaren arteko ratioa (C max /MIC), eta azkenik, farmakoaren kontzentrazioen 24 orduko kurba azpiko azaleraren (AUC) eta MICaren arteko erlazioa (AUC/MIC) [23,24]. Indize horiek balio jakin bat lortu beharko dute eraginkortasuna bermatzeko.…”

Section: Indize Farmakozinetiko/farmakodinamikoakunclassified

“…luzeak erabiltzen dira. Talde honen barruan daude aminoglikosidoak eta fluorokinolonak, besteak beste [23,24].…”

Section: Indize Farmakozinetiko/farmakodinamikoakunclassified

“…Zenbait kasutan, bereziki behar den T >MIC altua denean, benabarneko perfusioa beharrezkoa izan daiteke. Talde honen barruan antibiotiko betalaktamikoak daude [23,24].…”

Section: Indize Farmakozinetiko/farmakodinamikoakunclassified

“…Antibiotiko-kontzentrazio altuek heriotza bakterianoa handitzen dute arinki, baina mikroorganismoen hazkuntza inhibituko dute luzaroko. Talde honetan erabiltzen diren indikadoreak AUC/MICa edo C max /MICa dira eta linezolid edo bankomizina bezalako antibiotikoak hartzen ditu barne [23,24].…”

Section: Indize Farmakozinetiko/farmakodinamikoakunclassified

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Analisi farmakozinetiko/farmakodinamikoa antimikrobianoen erabilera hobetzeko gaixo larrietan

Soraluce

Rodríguez-Gascón

Isla

2018

EKAIA

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Laburpena: Azken urteotan infekzioen tratamendua mundu mailako osasun publikoko arazo bilakatu da, erresistentzien garapenaren ondorioz, bakterio multirresistenteen agerpena izugarri igo baita. Antibiotiko berrien gabeziak merkatuan daudenen dosifikazioen optimizazioaren premia areagotzen du. Zenbait pazientetan, gaixo larrietan esaterako, aipatutakoa egitea bereziki zaila suerta daiteke. Izan ere, beraien egoera fisiopatologikoa dela eta, medikamentuen farmakozinetika eta farmakodinamia eraldatuta daukate. Analisi farmakozinetiko/farmakodinamikoak, Monte Carlo simulazioekin batera, dosifikazio-erregimenen optimizazioa ahalbidetzen du. Horrela, tratamenduaren arrakasta bermatu eta erresistentzien agerpena ekiditen da.Hitz gakoak: Antibiotikoak, populazio-farmakozinetika, analisi farmakozinetiko/farmakodinamikoa, Monte Carlo simulazioa.Abstract: Nowadays, the treatment of infectious diseases has become a global health issue, due to multi-resistant antibiotic bacteria. The lack of new antibiotics enhances urgent need for current antimicrobials' dosing regimens optimization. This could become an extremely challenging duty when treating some kind of patients, such as the critically ill; as due to their physiophatological situation, both pharmacokinetics and pharmacodynamics might be altered. PK/PD analysis, together with Monte Carlo Simulation, might be a useful tool in order to optimize dosing regimens of antibiotic agents and, therefore, improve clinical outcome and diminish emergence of resistances.

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New advances in management and treatment of cardiac implantable electronic devices infections

Russo,

Serraino,

Serapide

et al. 2023

Infection

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Cardiac implantable electronic devices (CIED) are increasingly used worldwide, and infection of these devices remains one of the most feared complications.CIED infections (CDIs) represent a challenge for physicians and the healthcare system in general as they require prolonged hospitalization and antibiotic treatment and are burdened by high mortality and high costs, so management of CDIs must be multidisciplinary.The exact incidence of CDIs is difficult to define, considering that it is influenced by various factors mainly represented by the implanted device and the type of procedure. Risk factors for CDIs could be divided into three categories: device related, patient related, and procedural related and the etiology is mainly sustained by Gram-positive bacteria; however, other etiologies cannot be underestimated. As a matter of fact, the two cornerstones in the treatment of these infections are device removal and antimicrobial treatment. Finally, therapeutic drug monitoring and PK/PD correlations should be encouraged in all patients with CDIs receiving antibiotic therapy and may result in a better clinical outcome and a reduction in antibiotic resistance and economic costs.In this narrative review, we look at what is new in the management of these difficult-to-treat infections.

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Pharmacokinetic/pharmacodynamic (PK/PD) considerations in the management of Gram-positive bacteraemia

Cited by 15 publications

References 100 publications

Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery

Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery

Analisi farmakozinetiko/farmakodinamikoa antimikrobianoen erabilera hobetzeko gaixo larrietan

New advances in management and treatment of cardiac implantable electronic devices infections

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