Pharmacokinetic/pharmacodynamic considerations for epilepsy – depression comorbidities

Banach, Monika; Popławska, Monika; Błaszczyk, Barbara; Borowicz, Kinga K.; Czuczwar, Stanisław J.

doi:10.1080/17425255.2016.1198319

Cited by 14 publications

(4 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there are many antidepressant drugs which can be safely administered to patients with epilepsy with depression, there are some antidepressants, identified pre-clinically, as potentially hazardous to this patient population with similar clinical data on this issue. These antidepressants include bupropion, clomipramine and maprotiline and their use in patients with epilepsy should be discouraged (Banach et al, 2016). The probability of pharmacokinetic interactions between AEDs and antidepressant drugs need to be considered.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological and non-pharmacological approaches to life threatening conditions in epilepsy

Błaszczyk¹,

Walczak

Ścirka

et al. 2020

Journal of Epileptology

Self Cite

View full text Add to dashboard Cite

Background. A higher degree of mortality may be attributed to patients with epilepsy. There are several main reasons responsible-sudden unexpected death in epilepsy (SUDEP), status epilepticus (SE) and central nervous system damage. Also, epilepsy associated accidents and suicidal attempts have to be highlighted. Aim. Epidemiology and therapeutic or preventive (pharmacological or non-pharmacological strategies) of the conditions increasing mortality have been reviewed so as to minimize the mortality rate in patients with epilepsy. Discussion and Conclusions. Generally, the treatment of convulsive SE entails the need to achieve rapid stabilization of a patient and an appropriate choice of antiepileptic drugs (AEDs) so as to stop seizure activity. In the event of no response the treatment has to be continued under general anaesthesia. For minimizing the risk of SUDEP in young adults or patients with childhood epilepsy, adequate treatments with AEDs must be initiated or possible surgery considered. Patients with uncontrolled epilepsy require AED optimization. Although a possible link between taking AEDs and increased suicidality is questionable, patients with epilepsy are advised to be evaluated for possible symptoms of depression or anxiety. Surgical treatment of epilepsy may increase the risk of depression development, so a careful psychiatric examination is recommended prior to surgery. Key words: status epilepticus • sudden • unexpected death in epilepsy • depression • suicide • injuries • epilepsy BACKGROUND Mortality in the cohort of epileptic patients is considerably higher than in the general population. It is estimated to be 1.6-11.4 times higher than in healthy people and the ratio for epileptic children may be between 5.3 and up to 9.0 times higher (Lathoo, Sander, 2005). The bigger risk of death in epileptic patients is attributed to a variety of factors, which may be classified into several types.

show abstract

Section: Discussionmentioning

confidence: 99%

“…However, drug monitoring may prove inevitable when the combined treatment with AEDs and antidepressants leads to an increase in seizure frequency or evident drug toxicity. On this basis, dose adjustments may be implemented (Banach et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological and non-pharmacological approaches to life threatening conditions in epilepsy

Błaszczyk¹,

Walczak

Ścirka

et al. 2020

Journal of Epileptology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In many cases, the influence antidepressant drugs on the seizure threshold refers to either acute or chronic dosing. The results are presented in Table 1 on the basis of data reviewed by Banach et al (2016).…”

Section: Antidepressant Drugs and Seizure Susceptibilitymentioning

confidence: 99%

“…Some antidepressants (citalopram, fluoxetine, sertraline) and the AEDs (felbamate and probably carbamazepine, lamotrigine, and phenytoin) (Auerbach et al, 2018) predispose patients to arrhythmias so there combined use is not recommended (Italiano et al, 2014). Some other adverse effects may accompany combined treatment with AEDs and antidepressants-reduced production of sweat and hypohydrosis, increased risk for hyponatremia (especially when carbamazepine is coadministered with antidepressants) (Banach et al, 2016).…”

Section: Possibly Pharmacodynamic Interactions Between Antiepileptic ...mentioning

confidence: 99%

Comorbid epilepsy and depression—pharmacokinetic and pharmacodynamic drug interactions

Miziak

Czuczwar²,

Pluta³

2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Background: Major depressive disorder may be encountered in 17% of patients with epilepsy and in patients with drug-resistant epilepsy its prevalence may reach 30%. This indicates that patients with epilepsy may require antidepressant treatment.Purpose: Both pharmacodynamic and pharmacokinetic interactions between antiepileptic (antiseizure) and antidepressant drugs have been reviewed. Also, data on the adverse effects of co-administration of antiepileptic with antidepressant drugs have been added. This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology.Methods: The review of relevant literature was confined to English-language publications in PUBMED databases. Table data show effects of antidepressants on the seizure susceptibility in experimental animals, results of pharmacodynamic interactions between antiepileptic and antidepressant drugs mainly derived from electroconvulsions in mice, as well as results concerning pharmacokinetic interactions between these drugs in clinical conditions.Conclusion: Antidepressant drugs may exert differentiated effects upon the convulsive threshold which may differ in their acute and chronic administration. Animal data indicate that chronic administration of antidepressants could reduce (mianserin, trazodone) or potentiate the anticonvulsant activity of some antiepileptics (fluoxetine, reboxetine, venlafaxine). There are also examples of neutral interactions (milnacipran).

show abstract

Psychiatrische Störungen

Hoppe¹

2020

Epileptische Anfälle Und Epilepsien Im Erwachsenenalter

View full text Add to dashboard Cite

Pharmacokinetic/pharmacodynamic considerations for epilepsy – depression comorbidities

Cited by 14 publications

References 114 publications

Pharmacological and non-pharmacological approaches to life threatening conditions in epilepsy

Pharmacological and non-pharmacological approaches to life threatening conditions in epilepsy

Comorbid epilepsy and depression—pharmacokinetic and pharmacodynamic drug interactions

Psychiatrische Störungen

Contact Info

Product

Resources

About