Pharmacokinetic, Pharmacodynamic, and Toxicology Study of Robenacoxib in Rainbow Trout (Oncorhynchus Mykiss)

Raulic, Juliette; Beaudry, Francis; Beauchamp, Guy; Jalenques, Marion; Summa, Noémie; Lair, Stéphane; Youcef, Wahiba Ait; Vergneau‐Grosset, Claire

doi:10.1638/2020-0130

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…To the best of the author's knowledge, there have been no previous RX studies in geese. No systemic or local adverse effects were observed following IV and PO administrations at a dose of 2–4 mg/kg in geese, as it was the case in sheep (Fadel et al, 2022), goats (Fadel et al, 2023), dogs (Jung et al, 2009), cats (King et al, 2013), rabbits (Jeffrey et al, 2023), rats (King et al, 2009), and rainbow trouts (Raulic et al, 2021).…”

Section: Discussionmentioning

confidence: 88%

Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus)

Fadel

Łebkowska‐Wieruszewska

Lisowski

et al. 2023

Vet Pharm & Therapeutics

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Robenacoxib (RX) is a veterinary cyclooxygenase‐2 selective inhibitor drug. It has never been tested on birds and is only labelled for use in cats and dogs. The purpose of this study was to assess its pharmacokinetics in geese after single intravenous (IV) and oral (PO) administrations. Four‐month healthy female geese (n = 8) were used. Geese were subjected to a two‐phase, single‐dose (2 mg/kg IV, 4 mg/kg PO), open, longitudinal study design with a four‐month washout period between the IV and the PO phases. Blood was collected from the left wing vein to heparinized tubes at 0, 0.085 (for IV only), 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 10, and 24 h. Plasma RX concentrations were measured using HPLC coupled to an UV detector, and the data were pharmacokinetically analysed using ThothPro™ 4.3 software in a non‐compartmental approach. Following IV administration, terminal elimination half‐life, volume of distribution, and total clearance were 0.35 h, 0.34 L/kg, and 0.68 L/h/kg, respectively. For the PO route, the mean peak plasma concentration was 6.78 μg/mL at 0.50 h. The t1/2λz was very short and significantly different between the IV and PO administrations (0.35 h IV vs. 0.99 h PO), suggesting the occurrence of a flip‐flop phenomenon. The Cl values corrected for the F% were significantly different between IV and PO administrations. It might have been a consequence of the longitudinal study design and the altered physiological and environmental conditions after a 4‐month washout period. The absolute oral F% computed with the AUC method surpassed 150%, but after normalizing it to t1/2λz, it was 46%. In conclusion, the administration of RX might not be suitable for geese, due to its short t1/2λz.

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Section: Discussionmentioning

confidence: 88%

Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus)

Fadel

Łebkowska‐Wieruszewska

Lisowski

et al. 2023

Vet Pharm & Therapeutics

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“…No systemic or local adverse effects were observed following the various routes of administration of RX at a dose of 2–4 mg/kg in goats. It was the case as well in sheep (Fadel et al, 2022), dogs (Jung et al, 2009), cats (King et al, 2013), rabbits (Jeffrey et al, 2023), rats (King et al, 2009) and rainbow trout (Raulic et al, 2021).…”

Section: Discussionmentioning

confidence: 93%

Pharmacokinetics of robenacoxib following single intravenous, subcutaneous and oral administrations in Baladi goats (Capra hircus)

Fadel

Łebkowska‐Wieruszewska

Zizzadoro

et al. 2023

Vet Pharm & Therapeutics

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The purpose of this study was to assess the pharmacokinetics of robenacoxib (RX), a COX‐2 selective non‐steroidal anti‐inflammatory drug, in goats after single intravenous (IV), subcutaneous (SC) and oral (PO) administrations. 5‐month‐old healthy female goats (n = 8) were used. The animals were subjected to a three‐phase, two‐dose (2 mg/kg IV, 4 mg/kg SC, PO) unblinded, parallel study design, with a four‐month washout period between the IV and SC treatment, and a one‐week period between the SC and PO treatment. Blood was drawn from the jugular vein in heparinized vacutainer tubes at 0, 0.085 (for IV only), 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 10 and 24 h. Plasma RX concentrations were measured using HPLC coupled to a UV multiple wavelength detector, and the data were pharmacokinetically analysed using ThothPro™ 4.3 software in a non‐compartmental approach. Following IV administration, terminal elimination half‐life, volume of distribution and total clearance were 0.32 h, 0.24 L/kg and 0.52 L/h/kg, respectively. For SC and PO, the mean peak plasma concentrations were 2.34 and 3.34 μg/mL at 1.50 and 0.50 h, respectively. The t1/2λz was significantly different between the IV and the extravascular (EV) administrations (0.32 h IV vs 1.37 h SC and 1.63 h PO), suggesting the occurrence of a flip‐flop phenomenon. The significant difference in Vd values between IV (0.24 L/kg) and EV (0.95 L/kg SC and 1.71 L/kg; corrected for F %) routes might have also triggered the t1/2λz difference. The absolute average SC and PO bioavailability were high (98% and 91%, respectively). In conclusion, the IV administration of RX might not be suitable for goats, due to its short t1/2λz. The EV routes, however, appear to be convenient for the drug's occasional use.

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“…Each included a general and ophthalmic examination under general anesthesia. Post-operatively, meloxicam (Metacam, Boerhinger Ingelheim Vetmedica, Duluth, GA, USA) at 0.5 mg/kg or robenacoxib (Onsior, Elanco US Inc., Greenfiled, IN, USA) at 2 mg/kg were injected in the epaxial muscles [15].…”

Section: Post-operative Follow-upmentioning

confidence: 99%

A Post-Operative Follow-Up of an Endangered Saltwater Fish Lensectomy for Cataract Management in a Public Aquarium: A Case Series

Pujol,

Lamglait,

Vanore

et al. 2023

Veterinary Sciences

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Mature cataracts can be a life-threatening condition in fish as it may result in anorexia. Lens extraction has been previously described in fish, but the long-term outcome of this procedure has not been evaluated. Eleven captive-bred adult fish housed in a public aquarium presented with unilateral (n = 3/11) or bilateral (n = 8/11) mature cataracts. All cases belonged to three endangered fish populations: striped bass (Morone saxatilis) originating from the Saint Lawrence River and Atlantic and spotted wolffish (Anarhichas lupus and Anarhichas minor). Pre-operatively, fish presented with anorexia, dark discoloration, abnormal position in the water column, skin abrasions, and/or decreased body condition scores. A lensectomy was performed in eleven fish, including a bilateral procedure in four fish, corresponding to fifteen eyes. Follow-up examinations were performed one to two weeks and one year post surgery. The main complication was self-resolving: corneal edema was present in 67% of eyes, persistent after a week in 47% of eyes, and resolved thereafter. Post-operatively, 73% of fish resumed feeding and regained a good body condition score. Persistent visual impairment post-surgery associated with anorexia required euthanasia in three out of eleven cases. The median time of death was 336 days post surgery (range: 27–1439 days) and three cases were still alive 1334 to 1425 days after the lensectomy. This was considered a favorable outcome for these older individuals with concurrent diseases.

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Pharmacokinetic, Pharmacodynamic, and Toxicology Study of Robenacoxib in Rainbow Trout (Oncorhynchus Mykiss)

Cited by 7 publications

References 32 publications

Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus)

Disposition kinetics of robenacoxib following intravenous and oral administration in geese (Anser anser domesticus)

Pharmacokinetics of robenacoxib following single intravenous, subcutaneous and oral administrations in Baladi goats (Capra hircus)

A Post-Operative Follow-Up of an Endangered Saltwater Fish Lensectomy for Cataract Management in a Public Aquarium: A Case Series

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